{"id":"vonoprazan-amoxicillin-with-berberine","safety":{"commonSideEffects":[{"rate":null,"effect":"Diarrhea"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Abdominal discomfort"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Taste disturbance"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Vonoprazan is a potassium-competitive acid blocker that inhibits the H+/K+-ATPase pump to reduce gastric acid secretion, creating an optimal pH environment for amoxicillin efficacy against H. pylori. Amoxicillin is a beta-lactam antibiotic that disrupts bacterial cell wall synthesis. Berberine, a plant alkaloid, provides additional antimicrobial activity against H. pylori and may enhance treatment efficacy through anti-inflammatory mechanisms.","oneSentence":"This combination uses vonoprazan to suppress gastric acid, amoxicillin to kill H. pylori bacteria, and berberine as an adjunctive antimicrobial and anti-inflammatory agent for H. pylori eradication.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:15:50.791Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Helicobacter pylori infection eradication"}]},"trialDetails":[{"nctId":"NCT07306988","phase":"PHASE4","title":"Eradication of Helicobacter Pylori Improves Metabolic Syndrome Through Modulation of Gut Microbiota.","status":"RECRUITING","sponsor":"Nanjing First Hospital, Nanjing Medical University","startDate":"2025-04-17","conditions":"HELICOBACTER PYLORI INFECTIONS, Metabolic Syndrome","enrollment":120}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Vonoprazan-Amoxicillin with Berberine","genericName":"Vonoprazan-Amoxicillin with Berberine","companyName":"Nanjing First Hospital, Nanjing Medical University","companyId":"nanjing-first-hospital-nanjing-medical-university","modality":"Small molecule","firstApprovalDate":"","aiSummary":"This combination uses vonoprazan to suppress gastric acid, amoxicillin to kill H. pylori bacteria, and berberine as an adjunctive antimicrobial and anti-inflammatory agent for H. pylori eradication. Used for Helicobacter pylori infection eradication.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}