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Vasopressin intravenous infusion
Vasopressin intravenous infusion is a Vasopressor agent; antidiuretic hormone Small molecule drug developed by University of Sao Paulo. It is currently FDA-approved for Variceal bleeding (esophageal varices), Hypotension/shock (septic shock, cardiogenic shock), Central diabetes insipidus. Also known as: Arginine Vasopressin, ADH, Pitressin.
Vasopressin is a peptide hormone that binds to vasopressin receptors (V1 and V2) to increase vascular tone, blood pressure, and water reabsorption in the kidneys.
Vasopressin is a peptide hormone that binds to vasopressin receptors (V1 and V2) to increase vascular tone, blood pressure, and water reabsorption in the kidneys. Used for Variceal bleeding (esophageal varices), Hypotension/shock (septic shock, cardiogenic shock), Central diabetes insipidus.
At a glance
| Generic name | Vasopressin intravenous infusion |
|---|---|
| Also known as | Arginine Vasopressin, ADH, Pitressin |
| Sponsor | University of Sao Paulo |
| Drug class | Vasopressor agent; antidiuretic hormone |
| Target | Vasopressin receptor V1a, V1b, and V2 |
| Modality | Small molecule |
| Therapeutic area | Cardiovascular; Endocrinology |
| Phase | FDA-approved |
Mechanism of action
Vasopressin acts as a potent vasoconstrictor through V1 receptor activation on vascular smooth muscle, increasing systemic vascular resistance and blood pressure. It also activates V2 receptors in the renal collecting duct to promote aquaporin-2 water channel insertion, increasing water reabsorption and reducing urine output. These combined effects make it useful in treating hypotension and variceal bleeding.
Approved indications
- Variceal bleeding (esophageal varices)
- Hypotension/shock (septic shock, cardiogenic shock)
- Central diabetes insipidus
Common side effects
- Hypertension
- Coronary vasoconstriction / myocardial ischemia
- Arrhythmias
- Hyponatremia (water intoxication)
- Abdominal cramping
- Pallor / peripheral vasoconstriction
Key clinical trials
- DDAVP for Pituitary Adenoma (NA)
- Bleeding Reduction in Acute and Chronic Kidney Patients Having Surgery (BRACKETS) Pilot Trial (PHASE3)
- CAlcium and VAsopressin Following Injury Early Resuscitation (CAVALIER) Trial (PHASE2)
- Terlipressin vs. Somatostatin in Cirrhotic Patients With Acute Gastrointestinal Bleeding and Acute Kidney Injury (NA)
- Vasopressin for Septic Shock Pragmatic Trial (PHASE4)
- Bleeding Prevention With Desmopressin for Allograft Kidney Biopsies (PHASE4)
- Systematic Use of DDAVP to Prevent Serum Sodium Overcorrection in Severe Hyponatremia (PHASE3)
- Safety Outcomes Post Kidney Biopsy - Randomized Clinical Evaluation of Efficacy of Desmopressin (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Vasopressin intravenous infusion CI brief — competitive landscape report
- Vasopressin intravenous infusion updates RSS · CI watch RSS
- University of Sao Paulo portfolio CI
Frequently asked questions about Vasopressin intravenous infusion
What is Vasopressin intravenous infusion?
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Related
- Drug class: All Vasopressor agent; antidiuretic hormone drugs
- Target: All drugs targeting Vasopressin receptor V1a, V1b, and V2
- Manufacturer: University of Sao Paulo — full pipeline
- Therapeutic area: All drugs in Cardiovascular; Endocrinology
- Indication: Drugs for Variceal bleeding (esophageal varices)
- Indication: Drugs for Hypotension/shock (septic shock, cardiogenic shock)
- Indication: Drugs for Central diabetes insipidus
- Also known as: Arginine Vasopressin, ADH, Pitressin
- Compare: Vasopressin intravenous infusion vs similar drugs
- Pricing: Vasopressin intravenous infusion cost, discount & access