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Vasopressin for Septic Shock Pragmatic Trial (VASSPR)
Life-threatening low blood pressure due to a serious infection is called "septic shock." Septic shock is treated with vasopressors, medications that raise blood pressure. Sometimes first-line vasopressors are inadequate, prompting addition of a second-line vasopressor called vasopressin. However, the threshold at which to start vasopressin remains unclear. This pragmatic, cluster-randomized, cluster-crossover trial will evaluate two different strategies for septic shock treatment commonly used in current practice, comparing a lower versus a higher threshold for adding vasopressin to first-line vasopressors.
Details
| Lead sponsor | Intermountain Health Care, Inc. |
|---|---|
| Phase | Phase 4 |
| Status | ACTIVE_NOT_RECRUITING |
| Enrolment | 2050 |
| Start date | 2024-02-01 |
| Completion | 2027-12 |
Conditions
- Septic Shock
Interventions
- Vasopressin
- Recommendation to use a lower initiation threshold for vasopressin
- Recommendation to use a higher initiation threshold for vasopressin
Primary outcomes
- 28-day all-cause mortality — 28 days
Death on or before study day 28
Countries
United States