{"id":"vasopressin-intravenous-infusion","safety":{"commonSideEffects":[{"rate":null,"effect":"Hypertension"},{"rate":null,"effect":"Coronary vasoconstriction / myocardial ischemia"},{"rate":null,"effect":"Arrhythmias"},{"rate":null,"effect":"Hyponatremia (water intoxication)"},{"rate":null,"effect":"Abdominal cramping"},{"rate":null,"effect":"Pallor / peripheral vasoconstriction"}]},"_chembl":{"chemblId":"CHEMBL1201528","moleculeType":"Protein"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Vasopressin acts as a potent vasoconstrictor through V1 receptor activation on vascular smooth muscle, increasing systemic vascular resistance and blood pressure. It also activates V2 receptors in the renal collecting duct to promote aquaporin-2 water channel insertion, increasing water reabsorption and reducing urine output. These combined effects make it useful in treating hypotension and variceal bleeding.","oneSentence":"Vasopressin is a peptide hormone that binds to vasopressin receptors (V1 and V2) to increase vascular tone, blood pressure, and water reabsorption in the kidneys.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:14:55.309Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Variceal bleeding (esophageal varices)"},{"name":"Hypotension/shock (septic shock, cardiogenic shock)"},{"name":"Central diabetes insipidus"}]},"trialDetails":[{"nctId":"NCT04569591","phase":"NA","title":"DDAVP for Pituitary Adenoma","status":"RECRUITING","sponsor":"National Institute of Neurological Disorders and Stroke (NINDS)","startDate":"2026-03-09","conditions":"Cushing's Disease, Pituitary Adenoma","enrollment":22},{"nctId":"NCT06337838","phase":"PHASE3","title":"Bleeding Reduction in Acute and Chronic Kidney Patients Having Surgery (BRACKETS) Pilot 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Shock","status":"UNKNOWN","sponsor":"Fundación Pública Andaluza para la gestión de la Investigación en Sevilla","startDate":"2022-10-11","conditions":"Septic Shock","enrollment":152},{"nctId":"NCT05806307","phase":"PHASE4","title":"Methods Decreasing Bleeding in Open Myomectomy","status":"UNKNOWN","sponsor":"Cairo University","startDate":"2023-03-15","conditions":"Misoprostol Allergy, Oxytocin Allergy, Tranexamic Acid Allergy","enrollment":105},{"nctId":"NCT05628558","phase":"","title":"Genetic Influence of Genetic Factors Influencing the Desmopressin's Efficacy in Mild/Moderate Hemophilia A","status":"UNKNOWN","sponsor":"Groupe Maladies hémorragiques de Bretagne","startDate":"2020-07-01","conditions":"Hemophilia A, Mild, Desmopressin, Factor VIII","enrollment":800},{"nctId":"NCT03696121","phase":"PHASE2","title":"Desmopressin for Reversal of Antiplatelet Drugs in Stroke Due to Haemorrhage","status":"COMPLETED","sponsor":"University of 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pressure, and water reabsorption in the kidneys. Used for Variceal bleeding (esophageal varices), Hypotension/shock (septic shock, cardiogenic shock), Central diabetes insipidus.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}