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variation of mannitol dose

University Hospital, Grenoble · FDA-approved active Small molecule

variation of mannitol dose is a Osmotic diuretic Small molecule drug developed by University Hospital, Grenoble. It is currently FDA-approved for Reduction of intracranial pressure in head trauma and neurosurgery, Reduction of intraocular pressure in acute glaucoma, Promotion of diuresis in acute kidney injury and oliguria.

Mannitol is an osmotic diuretic that draws fluid into the renal tubules and bloodstream to reduce intracranial pressure and promote diuresis.

Mannitol is an osmotic diuretic that draws fluid into the renal tubules and bloodstream to reduce intracranial pressure and promote diuresis. Used for Reduction of intracranial pressure in head trauma and neurosurgery, Reduction of intraocular pressure in acute glaucoma, Promotion of diuresis in acute kidney injury and oliguria.

At a glance

Generic namevariation of mannitol dose
SponsorUniversity Hospital, Grenoble
Drug classOsmotic diuretic
ModalitySmall molecule
Therapeutic areaNeurology, Ophthalmology, Critical Care
PhaseFDA-approved

Mechanism of action

Mannitol works by creating an osmotic gradient in the kidney that prevents water reabsorption in the tubules, thereby increasing urine output and reducing total body fluid volume. This osmotic effect also reduces intracranial and intraocular pressure by drawing fluid from the brain and eye tissues into the intravascular space. Dose variations allow titration of the diuretic and pressure-reducing effects based on clinical need.

Approved indications

Common side effects

Key clinical trials

Primary sources

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SourceUsed for
ClinicalTrials.govTrial enrolment, design, endpoints, results

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Frequently asked questions about variation of mannitol dose

What is variation of mannitol dose?

variation of mannitol dose is a Osmotic diuretic drug developed by University Hospital, Grenoble, indicated for Reduction of intracranial pressure in head trauma and neurosurgery, Reduction of intraocular pressure in acute glaucoma, Promotion of diuresis in acute kidney injury and oliguria.

How does variation of mannitol dose work?

Mannitol is an osmotic diuretic that draws fluid into the renal tubules and bloodstream to reduce intracranial pressure and promote diuresis.

What is variation of mannitol dose used for?

variation of mannitol dose is indicated for Reduction of intracranial pressure in head trauma and neurosurgery, Reduction of intraocular pressure in acute glaucoma, Promotion of diuresis in acute kidney injury and oliguria.

Who makes variation of mannitol dose?

variation of mannitol dose is developed and marketed by University Hospital, Grenoble (see full University Hospital, Grenoble pipeline at /company/university-hospital-grenoble).

What drug class is variation of mannitol dose in?

variation of mannitol dose belongs to the Osmotic diuretic class. See all Osmotic diuretic drugs at /class/osmotic-diuretic.

What development phase is variation of mannitol dose in?

variation of mannitol dose is FDA-approved (marketed).

What are the side effects of variation of mannitol dose?

Common side effects of variation of mannitol dose include Dehydration, Electrolyte imbalance (hypernatremia, hypokalemia), Rebound intracranial pressure elevation, Headache, Nausea and vomiting, Thrombophlebitis at injection site.

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