{"id":"variation-of-mannitol-dose","safety":{"commonSideEffects":[{"rate":null,"effect":"Dehydration"},{"rate":null,"effect":"Electrolyte imbalance (hypernatremia, hypokalemia)"},{"rate":null,"effect":"Rebound intracranial pressure elevation"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Nausea and vomiting"},{"rate":null,"effect":"Thrombophlebitis at injection site"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Mannitol works by creating an osmotic gradient in the kidney that prevents water reabsorption in the tubules, thereby increasing urine output and reducing total body fluid volume. This osmotic effect also reduces intracranial and intraocular pressure by drawing fluid from the brain and eye tissues into the intravascular space. Dose variations allow titration of the diuretic and pressure-reducing effects based on clinical need.","oneSentence":"Mannitol is an osmotic diuretic that draws fluid into the renal tubules and bloodstream to reduce intracranial pressure and promote diuresis.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:14:55.506Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Reduction of intracranial pressure in head trauma and neurosurgery"},{"name":"Reduction of intraocular pressure in acute glaucoma"},{"name":"Promotion of diuresis in acute kidney injury and oliguria"}]},"trialDetails":[{"nctId":"NCT03105843","phase":"PHASE4","title":"Sensory-Mechanical Responses to Eucapneic Voluntary Hyperventilation and Mannitol","status":"RECRUITING","sponsor":"Dr. Diane Lougheed","startDate":"2022-03-01","conditions":"Asthma, Cough, Cough Variant Asthma","enrollment":30},{"nctId":"NCT01064245","phase":"NA","title":"Physiology of Cough in Asthma: Comparison of Sensory-Mechanical Responses to Mannitol and Methacholine Challenge Tests","status":"COMPLETED","sponsor":"Dr. Diane Lougheed","startDate":"2010-02-01","conditions":"Asthma, Cough Variant Asthma","enrollment":29},{"nctId":"NCT02373735","phase":"NA","title":"Effect of SVV Guided Fluid Therapy on Blood Loss and Postoperative Outcomes","status":"COMPLETED","sponsor":"Asan Medical Center","startDate":"2015-03","conditions":"Bladder Cancer","enrollment":64},{"nctId":"NCT00795587","phase":"PHASE4","title":"Comparison of 2 Doses of Mannitol on Post Traumatic Intracranial Hypertension and Cerebral Monitoring","status":"TERMINATED","sponsor":"University Hospital, Grenoble","startDate":"2008-10","conditions":"Traumatic Brain Injury, Intracranial Hypertension","enrollment":3},{"nctId":"NCT01048684","phase":"NA","title":"Comparison of Two Doses of Mannitol on Brain Relaxation During Supratentorial Craniotomy","status":"COMPLETED","sponsor":"Centre hospitalier de l'Université de Montréal (CHUM)","startDate":"2010-04","conditions":"Brain Tumor, Intracranial Pressure","enrollment":80}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":3,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"variation of mannitol dose","genericName":"variation of mannitol dose","companyName":"University Hospital, Grenoble","companyId":"university-hospital-grenoble","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Mannitol is an osmotic diuretic that draws fluid into the renal tubules and bloodstream to reduce intracranial pressure and promote diuresis. Used for Reduction of intracranial pressure in head trauma and neurosurgery, Reduction of intraocular pressure in acute glaucoma, Promotion of diuresis in acute kidney injury and oliguria.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}