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Tree SLIT-tablet
Tree SLIT-tablet is a sublingual immunotherapy that desensitizes the immune system to tree pollen allergens by gradually exposing patients to increasing doses of allergen extract.
Tree SLIT-tablet is a sublingual immunotherapy that desensitizes the immune system to tree pollen allergens by gradually exposing patients to increasing doses of allergen extract. Used for Allergic rhinitis and/or allergic asthma caused by tree pollen allergens.
At a glance
| Generic name | Tree SLIT-tablet |
|---|---|
| Sponsor | ALK-Abelló A/S |
| Drug class | Allergen immunotherapy (sublingual tablet) |
| Target | Tree pollen allergen epitopes |
| Modality | Small molecule |
| Therapeutic area | Immunology / Allergy |
| Phase | Phase 3 |
Mechanism of action
SLIT (sublingual immunotherapy) works by placing allergen tablets under the tongue, where they interact with immune cells in the oral mucosa. This repeated, controlled exposure induces immune tolerance through regulatory T cell expansion and shift from Th2 to Th1/Treg responses, reducing allergic symptoms and the need for symptomatic medications. The mechanism is similar to subcutaneous immunotherapy but delivered via the sublingual route for improved tolerability and convenience.
Approved indications
- Allergic rhinitis and/or allergic asthma caused by tree pollen allergens
Common side effects
- Oral pruritus
- Throat irritation
- Mouth edema
- Local allergic reactions at sublingual site
Key clinical trials
- A Study in Children and Adolescents With Birch Pollen-induced Rhinoconjunctivitis (PHASE3)
- A Dose-response Evaluation of the SQ Tree SLIT-tablet Using an Environmental Exposure Chamber (PHASE2)
- Tolerability of SLIT With LAIS® 2-Tree Allergoid Tablets
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |