{"id":"tree-slit-tablet","safety":{"commonSideEffects":[{"rate":null,"effect":"Oral pruritus"},{"rate":null,"effect":"Throat irritation"},{"rate":null,"effect":"Mouth edema"},{"rate":null,"effect":"Local allergic reactions at sublingual site"}]},"_chembl":{"chemblId":"CHEMBL2107927","moleculeType":"Unknown"},"_dailymed":null,"mechanism":{"_ai_source":"anthropic-haiku","explanation":"SLIT (sublingual immunotherapy) works by placing allergen tablets under the tongue, where they interact with immune cells in the oral mucosa. This repeated, controlled exposure induces immune tolerance through regulatory T cell expansion and shift from Th2 to Th1/Treg responses, reducing allergic symptoms and the need for symptomatic medications. The mechanism is similar to subcutaneous immunotherapy but delivered via the sublingual route for improved tolerability and convenience.","oneSentence":"Tree SLIT-tablet is a sublingual immunotherapy that desensitizes the immune system to tree pollen allergens by gradually exposing patients to increasing doses of allergen extract.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:40:00.008Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Allergic rhinitis and/or allergic asthma caused by tree pollen allergens"}]},"trialDetails":[{"nctId":"NCT04878354","phase":"PHASE3","title":"A Study in Children and Adolescents With Birch Pollen-induced Rhinoconjunctivitis","status":"COMPLETED","sponsor":"ALK-Abelló A/S","startDate":"2021-04-07","conditions":"Allergy","enrollment":952},{"nctId":"NCT02481856","phase":"PHASE2","title":"A Dose-response Evaluation of the SQ Tree SLIT-tablet Using an Environmental Exposure Chamber","status":"COMPLETED","sponsor":"ALK-Abelló A/S","startDate":"2015-06","conditions":"Allergic Rhinoconjunctivitis","enrollment":219},{"nctId":"NCT02553590","phase":"","title":"Tolerability of SLIT With LAIS® 2-Tree Allergoid Tablets","status":"COMPLETED","sponsor":"University Hospital of Cologne","startDate":"2015-01","conditions":"Allergic Rhinitis","enrollment":160}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":16,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Tree SLIT-tablet","genericName":"Tree SLIT-tablet","companyName":"ALK-Abelló A/S","companyId":"alk-abell-a-s","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Tree SLIT-tablet is a sublingual immunotherapy that desensitizes the immune system to tree pollen allergens by gradually exposing patients to increasing doses of allergen extract. Used for Allergic rhinitis and/or allergic asthma caused by tree pollen allergens.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":1,"withResults":1},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}