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Tramadol with ropivacaine
Tramadol with ropivacaine is a Opioid analgesic combined with local anesthetic Small molecule drug developed by Aristotle University Of Thessaloniki. It is currently FDA-approved for Acute and chronic pain management, Perioperative and postoperative pain control. Also known as: TR.
Tramadol provides systemic opioid analgesia while ropivacaine delivers local anesthetic blockade of nerve conduction at the site of administration.
Tramadol provides systemic opioid analgesia while ropivacaine delivers local anesthetic blockade of nerve conduction at the site of administration. Used for Acute and chronic pain management, Perioperative and postoperative pain control.
At a glance
| Generic name | Tramadol with ropivacaine |
|---|---|
| Also known as | TR |
| Sponsor | Aristotle University Of Thessaloniki |
| Drug class | Opioid analgesic combined with local anesthetic |
| Target | Mu-opioid receptor (tramadol); voltage-gated sodium channels (ropivacaine) |
| Modality | Small molecule |
| Therapeutic area | Pain management |
| Phase | FDA-approved |
Mechanism of action
Tramadol is a centrally-acting synthetic opioid that inhibits reuptake of norepinephrine and serotonin while acting as a weak mu-opioid receptor agonist, producing systemic pain relief. Ropivacaine is a local anesthetic that blocks sodium channels in nerve membranes, preventing action potential propagation and producing regional anesthesia. The combination provides both systemic and local pain control.
Approved indications
- Acute and chronic pain management
- Perioperative and postoperative pain control
Common side effects
- Nausea
- Dizziness
- Constipation
- Local injection site reactions
- Headache
Key clinical trials
- Opioid-Free Pain Protocol After Shoulder Arthroplasty (PHASE4)
- Tramadol / Magnesium in Ropivacaine Solution in UG-bilateral TAP Block and Analgesia in Robotic Radical Prostatectomy (NA)
- TAP Block With Lidocaine and Ropivacaine 0.2% (0.4 ml/kg/Side) for Pain and Opioid Reduction After Hysterectomy (NA)
- Erector Spinae Plane Block in Uniportal VATS
- Effect of Opioid-free Anesthesia on PostOperative Nausea and Vomiting in Patients Undergoing Video-assisted Thoracoscopic Surgery (NA)
- The Effect of Intravenous Infusion of Tramadol-ondansetron on Recovery After Caesarean Section.
- Opioid Free Anesthesia-Analgesia Strategy and Surgical Stress in Elective Open Abdominal Aortic Aneurysm Repair (PHASE4)
- Fascia Iliaca Compartment Block and Tramadol for Analgesia in Hip Fracture (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Tramadol with ropivacaine CI brief — competitive landscape report
- Tramadol with ropivacaine updates RSS · CI watch RSS
- Aristotle University Of Thessaloniki portfolio CI
Frequently asked questions about Tramadol with ropivacaine
What is Tramadol with ropivacaine?
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Related
- Drug class: All Opioid analgesic combined with local anesthetic drugs
- Target: All drugs targeting Mu-opioid receptor (tramadol); voltage-gated sodium channels (ropivacaine)
- Manufacturer: Aristotle University Of Thessaloniki — full pipeline
- Therapeutic area: All drugs in Pain management
- Indication: Drugs for Acute and chronic pain management
- Indication: Drugs for Perioperative and postoperative pain control
- Also known as: TR
- Compare: Tramadol with ropivacaine vs similar drugs
- Pricing: Tramadol with ropivacaine cost, discount & access