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total intravenous anaesthesia with Propofol.
total intravenous anaesthesia with Propofol. is a Intravenous sedative-hypnotic Small molecule drug developed by Centre Hospitalier Universitaire Dijon. It is currently FDA-approved for Induction of general anesthesia in adults and children, Maintenance of general anesthesia via continuous infusion, Sedation of intubated patients in intensive care units.
Propofol is a rapid-acting intravenous sedative-hypnotic that enhances inhibitory GABA neurotransmission in the central nervous system to produce unconsciousness and anesthesia.
Propofol is a rapid-acting intravenous sedative-hypnotic that enhances inhibitory GABA neurotransmission in the central nervous system to produce unconsciousness and anesthesia. Used for Induction of general anesthesia in adults and children, Maintenance of general anesthesia via continuous infusion, Sedation of intubated patients in intensive care units.
At a glance
| Generic name | total intravenous anaesthesia with Propofol. |
|---|---|
| Sponsor | Centre Hospitalier Universitaire Dijon |
| Drug class | Intravenous sedative-hypnotic |
| Target | GABA-A receptor |
| Modality | Small molecule |
| Therapeutic area | Anesthesiology |
| Phase | FDA-approved |
Mechanism of action
Propofol acts as a positive allosteric modulator of GABA-A receptors, increasing chloride ion influx and neuronal hyperpolarization. This results in rapid onset of sedation and unconsciousness suitable for induction and maintenance of general anesthesia. Total intravenous anesthesia (TIVA) with propofol provides continuous IV infusion for complete anesthetic management without volatile agents.
Approved indications
- Induction of general anesthesia in adults and children
- Maintenance of general anesthesia via continuous infusion
- Sedation of intubated patients in intensive care units
Common side effects
- Hypotension
- Respiratory depression
- Bradycardia
- Injection site pain
- Apnea
- Propofol infusion syndrome (with prolonged high-dose infusion)
Key clinical trials
- Total Intravenous and Balanced Anesthesia in Diabetic Patients Undergoing Video-Assisted Thoracoscopy (PHASE4)
- Hemodynamic Effects of Remimazolam vs Propofol During Robot-assisted Gynecologic Surgery (NA)
- Comparison of Target-Controlled and Manual Total Intravenous Anesthesia in Supratentorial Surgery (NA)
- Anesthesia Maintenance With Target-controlled Infusion of Propofol and Remifentanil at Fixed Ratio (PHASE4)
- The Effect of Intravenous Versus Volatile Anesthesia on Postoperative Cognitive Dysfunction in Elderly Patients (NA)
- Comparison of Anesthetic Techniques for Early Recovery After Ankle Arthroscopy (NA)
- Evaluate the Protective Effect of Conditioning With Sevoflurane on the Myocardium (PHASE4)
- Comparing Inhalation and Total Intravenous Anesthesia Methods
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- total intravenous anaesthesia with Propofol. CI brief — competitive landscape report
- total intravenous anaesthesia with Propofol. updates RSS · CI watch RSS
- Centre Hospitalier Universitaire Dijon portfolio CI
Frequently asked questions about total intravenous anaesthesia with Propofol.
What is total intravenous anaesthesia with Propofol.?
How does total intravenous anaesthesia with Propofol. work?
What is total intravenous anaesthesia with Propofol. used for?
Who makes total intravenous anaesthesia with Propofol.?
What drug class is total intravenous anaesthesia with Propofol. in?
What development phase is total intravenous anaesthesia with Propofol. in?
What are the side effects of total intravenous anaesthesia with Propofol.?
What does total intravenous anaesthesia with Propofol. target?
Related
- Drug class: All Intravenous sedative-hypnotic drugs
- Target: All drugs targeting GABA-A receptor
- Manufacturer: Centre Hospitalier Universitaire Dijon — full pipeline
- Therapeutic area: All drugs in Anesthesiology
- Indication: Drugs for Induction of general anesthesia in adults and children
- Indication: Drugs for Maintenance of general anesthesia via continuous infusion
- Indication: Drugs for Sedation of intubated patients in intensive care units
- Compare: total intravenous anaesthesia with Propofol. vs similar drugs
- Pricing: total intravenous anaesthesia with Propofol. cost, discount & access