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Topiramate; Carbamazepine; Valproate
Topiramate; Carbamazepine; Valproate is a Anticonvulsants Small molecule drug developed by Johnson & Johnson Pharmaceutical Research & Development, L.L.C.. It is currently in Phase 3 development for Partial onset seizures, Generalized seizures, Migraine prophylaxis.
Topiramate is an anticonvulsant that acts as a voltage-dependent sodium channel blocker, whereas Carbamazepine is a tricyclic compound that stabilizes inactivated sodium channels, and Valproate is a fatty acid with anticonvulsant properties.
Topiramate is an anticonvulsant that acts as a voltage-dependent sodium channel blocker, whereas Carbamazepine is a tricyclic compound that stabilizes inactivated sodium channels, and Valproate is a fatty acid with anticonvulsant properties. Used for Partial onset seizures, Generalized seizures, Migraine prophylaxis.
At a glance
| Generic name | Topiramate; Carbamazepine; Valproate |
|---|---|
| Sponsor | Johnson & Johnson Pharmaceutical Research & Development, L.L.C. |
| Drug class | Anticonvulsants |
| Target | Voltage-dependent sodium channels |
| Modality | Small molecule |
| Therapeutic area | Neurology |
| Phase | Phase 3 |
Mechanism of action
Topiramate's mechanism of action is thought to involve the blockade of voltage-dependent sodium channels, which reduces the frequency of action potentials in neurons. Carbamazepine, on the other hand, stabilizes inactivated sodium channels, which prevents the excessive neuronal firing that can lead to seizures. Valproate's exact mechanism is not fully understood, but it is thought to involve the modulation of GABA receptors and the inhibition of voltage-dependent sodium channels.
Approved indications
- Partial onset seizures
- Generalized seizures
- Migraine prophylaxis
Common side effects
- Dizziness
- Headache
- Fatigue
- Nausea
- Drowsiness
Key clinical trials
- Population Pharmacokinetics of Antiepileptic in Pediatrics
- Low vs. Standard Daily Doses of Antiepileptic Drugs in Newly Diagnosed, Previously Untreated Epilepsy(STANDLOW) (PHASE4)
- Efficacy and Safety of Perampanel in Combination in Glioma-refractory Epilepsy (NA)
- Safety of Autologous MSC Infusion to Treat Epilepsy (PHASE1, PHASE2)
- Multicentre Study on Rapid Versus Slow Withdrawal of Antiepileptic Monotherapy (NA)
- Characterization of Epilepsy Patients BEEP 2b (PHASE1)
- Tetra-O-Methyl Nordihydroguaiaretic Acid in Treating Patients With Recurrent High-Grade Glioma (PHASE1, PHASE2)
- Pharmacovigilance in Gerontopsychiatric Patients (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Topiramate; Carbamazepine; Valproate CI brief — competitive landscape report
- Topiramate; Carbamazepine; Valproate updates RSS · CI watch RSS
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C. portfolio CI
Frequently asked questions about Topiramate; Carbamazepine; Valproate
What is Topiramate; Carbamazepine; Valproate?
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Who makes Topiramate; Carbamazepine; Valproate?
What drug class is Topiramate; Carbamazepine; Valproate in?
What development phase is Topiramate; Carbamazepine; Valproate in?
What are the side effects of Topiramate; Carbamazepine; Valproate?
What does Topiramate; Carbamazepine; Valproate target?
Related
- Drug class: All Anticonvulsants drugs
- Target: All drugs targeting Voltage-dependent sodium channels
- Manufacturer: Johnson & Johnson Pharmaceutical Research & Development, L.L.C. — full pipeline
- Therapeutic area: All drugs in Neurology
- Indication: Drugs for Partial onset seizures
- Indication: Drugs for Generalized seizures
- Indication: Drugs for Migraine prophylaxis