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Topical anesthetic
Topical anesthetic is a Local anesthetic Small molecule drug developed by University of Campinas, Brazil. It is currently FDA-approved for Topical pain relief and local anesthesia for minor skin procedures, Surface anesthesia for minor wounds and abrasions. Also known as: Topical Formulation, treatment, Centrix LolliCaine 2% xylocaine with 20% benzocaine, EMLA® (Eutectic Mixture of Local Anesthetics).
Topical anesthetics block sodium channels in nerve fibers to prevent pain signal transmission at the site of application.
Topical anesthetics are local anesthetics used to numb the surface of a body part, available in various forms such as creams, ointments, aerosols, sprays, lotions, and jellies. They can be used to numb areas such as the skin, the front of the eyeball, the inside of the nose, ear, or throat, the anus, and the genital area.
At a glance
| Generic name | Topical anesthetic |
|---|---|
| Also known as | Topical Formulation, treatment, Centrix LolliCaine 2% xylocaine with 20% benzocaine, EMLA® (Eutectic Mixture of Local Anesthetics) |
| Sponsor | University of Campinas, Brazil |
| Drug class | Local anesthetic |
| Target | Voltage-gated sodium channels |
| Modality | Small molecule |
| Therapeutic area | Pain management / Dermatology |
| Phase | FDA-approved |
Mechanism of action
These agents work by inhibiting voltage-gated sodium channels in peripheral nerves, preventing depolarization and action potential propagation. This results in local numbing of the skin or mucous membranes where applied, without systemic effects. Common topical anesthetics include lidocaine, benzocaine, and prilocaine.
Approved indications
- Topical pain relief and local anesthesia for minor skin procedures
- Surface anesthesia for minor wounds and abrasions
Common side effects
- Local skin irritation or erythema
- Allergic contact dermatitis
- Systemic toxicity (if absorbed in large quantities)
Key clinical trials
- Comparison of 4 Methods of Eye Drops for Pupil Dilation in Diabetic Patients (NA)
- Little NIRVANA for Pediatric Pain and Anxiety (NA)
- DaxibotulinumtoxinA for Blepharospasm (PHASE2)
- Vectored Thermal Pulsation, Intense Pulsed Light, and Eyelid Warm Compress Therapies for MGD (NA)
- This Clinical Trial Aims to Compare the Effectiveness of Two Intra-pulpal Cryotherapy Techniques-Endo-ice and Ice Sticks-in Decreasing Intra-operative Pain and Enhancing the Success of Local Anesthesia During Pulpectomy of Mandibular Molars With Symptomatic Irreversible Pulpitis. (NA)
- EMLA Topical Cream for Treatment of Pain in Patients Receiving Intra-Dermal Technetium 99 Injections for Lymphoscintigraphy for Skin Cancers (PHASE2)
- Efficacy and Durability of a Personalized Treat-and-extend Regimen of Faricimab for Treatment-naive Polypoidal Choroidal Vasculopathy (PHASE3)
- Automated Applanation Tonometry - Updated (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Topical anesthetic CI brief — competitive landscape report
- Topical anesthetic updates RSS · CI watch RSS
- University of Campinas, Brazil portfolio CI
Frequently asked questions about Topical anesthetic
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Related
- Drug class: All Local anesthetic drugs
- Target: All drugs targeting Voltage-gated sodium channels
- Manufacturer: University of Campinas, Brazil — full pipeline
- Therapeutic area: All drugs in Pain management / Dermatology
- Indication: Drugs for Topical pain relief and local anesthesia for minor skin procedures
- Indication: Drugs for Surface anesthesia for minor wounds and abrasions
- Also known as: Topical Formulation, treatment, Centrix LolliCaine 2% xylocaine with 20% benzocaine, EMLA® (Eutectic Mixture of Local Anesthetics)
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing