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Tamoxifen and GnRH analogue
Tamoxifen and GnRH analogue is a Selective estrogen receptor modulator (SERM) and Gonadotropin-releasing hormone (GnRH) analogue Small molecule drug developed by GBG Forschungs GmbH. It is currently in Phase 3 development for Treatment of hormone receptor-positive metastatic breast cancer, Treatment of hormone-sensitive breast cancer. Also known as: TRENATONE, ZOLADEX.
Tamoxifen acts as a selective estrogen receptor modulator (SERM) to inhibit estrogen's proliferative effects on breast cancer cells, while GnRH analogue works by downregulating GnRH receptors in the pituitary gland, leading to decreased gonadotropin secretion and subsequently reduced estrogen production.
Tamoxifen acts as a selective estrogen receptor modulator (SERM) to inhibit estrogen's proliferative effects on breast cancer cells, while GnRH analogue works by downregulating GnRH receptors in the pituitary gland, leading to decreased gonadotropin secretion and subsequently reduced estrogen production. Used for Treatment of hormone receptor-positive metastatic breast cancer, Treatment of hormone-sensitive breast cancer.
At a glance
| Generic name | Tamoxifen and GnRH analogue |
|---|---|
| Also known as | TRENATONE, ZOLADEX |
| Sponsor | GBG Forschungs GmbH |
| Drug class | Selective estrogen receptor modulator (SERM) and Gonadotropin-releasing hormone (GnRH) analogue |
| Target | Estrogen receptor and GnRH receptor |
| Modality | Small molecule |
| Therapeutic area | Oncology |
| Phase | Phase 3 |
Mechanism of action
Tamoxifen binds to estrogen receptors on breast cancer cells, preventing estrogen from binding and stimulating cell growth. This results in the inhibition of estrogen's proliferative effects on breast cancer cells. GnRH analogue, on the other hand, works by binding to GnRH receptors in the pituitary gland, leading to a decrease in gonadotropin secretion. This decrease in gonadotropin secretion subsequently results in reduced estrogen production, which can help to slow the growth of hormone receptor-positive breast cancer cells.
Approved indications
- Treatment of hormone receptor-positive metastatic breast cancer
- Treatment of hormone-sensitive breast cancer
Common side effects
- Hot flashes
- Vaginal discharge
- Nausea
- Headache
- Fatigue
Key clinical trials
- Functional Imaging in Prediction of Response to Abemaciclib for Advanced Hormone Receptor-Positive, HER2-Negative Breast Cancer (PHASE2)
- Triptorelin With Either Exemestane or Tamoxifen in Treating Premenopausal Women With Hormone-Responsive Breast Cancer (PHASE3)
- Suppression of Ovarian Function With Either Tamoxifen or Exemestane Compared With Tamoxifen Alone in Treating Premenopausal Women With Hormone-Responsive Breast Cancer (PHASE3)
- TRADE: Dose Escalation Tolerability of Abemaciclib in HR+ HER2- Early Stage Breast Cancer (PHASE2)
- Study of Bone Mineral Density in Women With Breast Cancer Treated With Triptorelin and Tamoxifen or Exemestane on Protocol IBCSG 25-02 (NA)
- Palbociclib for HR Positive / HER2-negative Isolated Locoregional Recurrence of Breast Cancer (PHASE3)
- Neoadjuvant Endocrine Therapy +/- the PI3K Inhibitor Inavolisib in HER2+, HR+, PIK3CA Mutant Early Breast Cancer (PHASE2)
- Dalpiciclib With Endocrine Therapy for Advanced Breast Cancer After CDK4/6 Inhibitor Failure (DAWNA-FES) (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Tamoxifen and GnRH analogue CI brief — competitive landscape report
- Tamoxifen and GnRH analogue updates RSS · CI watch RSS
- GBG Forschungs GmbH portfolio CI
Frequently asked questions about Tamoxifen and GnRH analogue
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Related
- Drug class: All Selective estrogen receptor modulator (SERM) and Gonadotropin-releasing hormone (GnRH) analogue drugs
- Target: All drugs targeting Estrogen receptor and GnRH receptor
- Manufacturer: GBG Forschungs GmbH — full pipeline
- Therapeutic area: All drugs in Oncology
- Indication: Drugs for Treatment of hormone receptor-positive metastatic breast cancer
- Indication: Drugs for Treatment of hormone-sensitive breast cancer
- Also known as: TRENATONE, ZOLADEX
- Compare: Tamoxifen and GnRH analogue vs similar drugs
- Pricing: Tamoxifen and GnRH analogue cost, discount & access