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Surgeon-Initiated Local Anesthetic
Surgeon-Initiated Local Anesthetic is a Local anesthetic Small molecule drug developed by University of Wisconsin, Madison. It is currently FDA-approved for Intraoperative and postoperative pain management during surgical procedures.
Surgeon-initiated local anesthetic blocks nerve conduction at the site of surgical administration to provide localized pain relief during and after surgical procedures.
Surgeon-initiated local anesthetic blocks nerve conduction at the site of surgical administration to provide localized pain relief during and after surgical procedures. Used for Intraoperative and postoperative pain management during surgical procedures.
At a glance
| Generic name | Surgeon-Initiated Local Anesthetic |
|---|---|
| Sponsor | University of Wisconsin, Madison |
| Drug class | Local anesthetic |
| Target | Voltage-gated sodium channels |
| Modality | Small molecule |
| Therapeutic area | Surgery/Anesthesia |
| Phase | FDA-approved |
Mechanism of action
Local anesthetics work by inhibiting sodium channel influx in nerve cell membranes, preventing depolarization and transmission of pain signals. When administered directly by the surgeon at the operative site, they provide regional anesthesia without systemic effects, reducing the need for general anesthesia or systemic opioids during surgery.
Approved indications
- Intraoperative and postoperative pain management during surgical procedures
Common side effects
- Local tissue irritation or inflammation
- Systemic toxicity (if absorbed in high concentrations)
- Allergic reaction (rare, depending on anesthetic agent)
Key clinical trials
- Randomized Study of an Analgesic Device Enabling Local Anesthetic Delivery and Neuromodulation After Shoulder/Foot Surgery (NA)
- Feasibility of an Analgesic Device Enabling Local Anesthetic Delivery and Neuromodulation After Shoulder/Foot Surgery (NA)
- Supra Inguinal Fascia Iliaca Block as Rescue Analgesia Following Total Hip Arthroplasty (NA)
- Comparison the Analgesic Efficacy of Ultrasonographic Bilateral TAP and Anesthetic Infiltration Into the Surgery Field for Laparoscopic Unilateral TEP Herniorrhaphy (NA)
- Transversus Abdominis Plane Block Compared to Local Anesthetic Wound Infiltration in Gynecologic Oncology Surgery (PHASE4)
- Efficacy of Oral Versus Intravenous Acetaminophen for Primary Pediatric Cleft Palate Repair (NA)
- Continuous Thoracic Paravertebral Analgesia for Video-assisted Thoracoscopic Surgery (NA)
- Analgesic Efficacy of Interscalene Nerve Block Versus Local Infiltration Analgesia Following Total Shoulder Arthroplasty (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Surgeon-Initiated Local Anesthetic CI brief — competitive landscape report
- Surgeon-Initiated Local Anesthetic updates RSS · CI watch RSS
- University of Wisconsin, Madison portfolio CI
Frequently asked questions about Surgeon-Initiated Local Anesthetic
What is Surgeon-Initiated Local Anesthetic?
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What is Surgeon-Initiated Local Anesthetic used for?
Who makes Surgeon-Initiated Local Anesthetic?
What drug class is Surgeon-Initiated Local Anesthetic in?
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What does Surgeon-Initiated Local Anesthetic target?
Related
- Drug class: All Local anesthetic drugs
- Target: All drugs targeting Voltage-gated sodium channels
- Manufacturer: University of Wisconsin, Madison — full pipeline
- Therapeutic area: All drugs in Surgery/Anesthesia
- Indication: Drugs for Intraoperative and postoperative pain management during surgical procedures
- Compare: Surgeon-Initiated Local Anesthetic vs similar drugs
- Pricing: Surgeon-Initiated Local Anesthetic cost, discount & access