Last reviewed 2026-04-23 · How we verify

Std-dose iv MgSO4

Magnesium sulfate acts as an anticonvulsant and vasodilator by inhibiting neuronal excitability and promoting blood vessel dilation.

Magnesium sulfate acts as an anticonvulsant and vasodilator by inhibiting neuronal excitability and promoting blood vessel dilation. Used for Pre-eclampsia prevention and treatment, Seizure prophylaxis in eclampsia.

At a glance

Mechanism of action

Magnesium sulfate's anticonvulsant properties are thought to be due to its ability to block voltage-gated calcium channels, reducing neuronal excitability and preventing seizures. Its vasodilatory effects are mediated through the relaxation of smooth muscle cells in blood vessels, leading to increased blood flow and decreased blood pressure.

Approved indications

• Pre-eclampsia prevention and treatment
• Seizure prophylaxis in eclampsia

Common side effects

• Flushing
• Dizziness
• Headache
• Nausea
• Vomiting
• Respiratory depression

Key clinical trials

• Two Doses of the Intravenous Magnesium Sulfate Versus the Standard Single Dose ,With/ Without the Nebulized Budesonide For the Management of the Severe Asthma Exacerbation in the Emergency Room; A Randomized Controlled Trial. (PHASE3)

Primary sources

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