{"id":"std-dose-iv-mgso4","safety":{"commonSideEffects":[{"rate":"10-20%","effect":"Flushing"},{"rate":"5-10%","effect":"Dizziness"},{"rate":"5-10%","effect":"Headache"},{"rate":"5-10%","effect":"Nausea"},{"rate":"2-5%","effect":"Vomiting"},{"rate":"null","effect":"Respiratory depression"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"Magnesium sulfate's anticonvulsant properties are thought to be due to its ability to block voltage-gated calcium channels, reducing neuronal excitability and preventing seizures. Its vasodilatory effects are mediated through the relaxation of smooth muscle cells in blood vessels, leading to increased blood flow and decreased blood pressure.","oneSentence":"Magnesium sulfate acts as an anticonvulsant and vasodilator by inhibiting neuronal excitability and promoting blood vessel dilation.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:53:39.044Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Pre-eclampsia prevention and treatment"},{"name":"Seizure prophylaxis in eclampsia"}]},"trialDetails":[{"nctId":"NCT02455687","phase":"PHASE3","title":"Two Doses of the Intravenous Magnesium Sulfate Versus the Standard Single Dose ,With/ Without the Nebulized Budesonide For the Management of the Severe Asthma Exacerbation in the Emergency Room; A Randomized Controlled Trial.","status":"UNKNOWN","sponsor":"Hamad Medical Corporation","startDate":"2015-06","conditions":"Bronchial Asthma","enrollment":240}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Std-dose iv MgSO4","genericName":"Std-dose iv MgSO4","companyName":"Hamad Medical Corporation","companyId":"hamad-medical-corporation","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Magnesium sulfate acts as an anticonvulsant and vasodilator by inhibiting neuronal excitability and promoting blood vessel dilation. Used for Pre-eclampsia prevention and treatment, Seizure prophylaxis in eclampsia.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}