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spinal administration of articaine
spinal administration of articaine is a Local anesthetic (amide) Small molecule drug developed by Reinier de Graaf Groep. It is currently in Phase 3 development for Spinal anesthesia for surgical procedures.
Articaine is a local anesthetic that blocks sodium channels in nerve fibers when administered into the spinal canal, preventing pain signal transmission.
Articaine is a local anesthetic that blocks sodium channels in nerve fibers when administered into the spinal canal, preventing pain signal transmission. Used for Spinal anesthesia for surgical procedures.
At a glance
| Generic name | spinal administration of articaine |
|---|---|
| Sponsor | Reinier de Graaf Groep |
| Drug class | Local anesthetic (amide) |
| Target | Voltage-gated sodium channels |
| Modality | Small molecule |
| Therapeutic area | Anesthesia |
| Phase | Phase 3 |
Mechanism of action
Articaine is an amide-type local anesthetic that works by inhibiting sodium influx through voltage-gated sodium channels in nerve cell membranes. When injected into the cerebrospinal fluid via spinal administration, it reversibly blocks the initiation and conduction of nerve impulses in sensory, motor, and autonomic nerves, producing localized anesthesia and analgesia in the lower body and lower extremities.
Approved indications
- Spinal anesthesia for surgical procedures
Common side effects
- Hypotension
- Bradycardia
- Headache (post-dural puncture)
- Transient neurological symptoms
- Nausea
Key clinical trials
- Decision Support for Intraoperative Low Blood Pressure (NA)
- Spinal Anesthesia With Articaine and Lidocaine for Outpatient Surgery. (PHASE3)
- Spinal Anesthesia With Articaine and Bupivacaine for Outpatient Lower Limb Surgery (PHASE3)
Primary sources
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| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- spinal administration of articaine CI brief — competitive landscape report
- spinal administration of articaine updates RSS · CI watch RSS
- Reinier de Graaf Groep portfolio CI
Frequently asked questions about spinal administration of articaine
What is spinal administration of articaine?
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What development phase is spinal administration of articaine in?
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Related
- Drug class: All Local anesthetic (amide) drugs
- Target: All drugs targeting Voltage-gated sodium channels
- Manufacturer: Reinier de Graaf Groep — full pipeline
- Therapeutic area: All drugs in Anesthesia
- Indication: Drugs for Spinal anesthesia for surgical procedures