{"id":"spinal-administration-of-articaine","safety":{"commonSideEffects":[{"rate":null,"effect":"Hypotension"},{"rate":null,"effect":"Bradycardia"},{"rate":null,"effect":"Headache (post-dural puncture)"},{"rate":null,"effect":"Transient neurological symptoms"},{"rate":null,"effect":"Nausea"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"anthropic-haiku","explanation":"Articaine is an amide-type local anesthetic that works by inhibiting sodium influx through voltage-gated sodium channels in nerve cell membranes. When injected into the cerebrospinal fluid via spinal administration, it reversibly blocks the initiation and conduction of nerve impulses in sensory, motor, and autonomic nerves, producing localized anesthesia and analgesia in the lower body and lower extremities.","oneSentence":"Articaine is a local anesthetic that blocks sodium channels in nerve fibers when administered into the spinal canal, preventing pain signal transmission.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:53:24.024Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Spinal anesthesia for surgical procedures"}]},"trialDetails":[{"nctId":"NCT02726620","phase":"NA","title":"Decision Support for Intraoperative Low Blood Pressure","status":"COMPLETED","sponsor":"Vanderbilt University Medical Center","startDate":"2017-01-05","conditions":"Hypotension","enrollment":22435},{"nctId":"NCT00247741","phase":"PHASE3","title":"Spinal Anesthesia With Articaine and Lidocaine for Outpatient Surgery.","status":"COMPLETED","sponsor":"St. Antonius Hospital","startDate":"2005-11","conditions":"Spinal Anesthesia","enrollment":80},{"nctId":"NCT00332735","phase":"PHASE3","title":"Spinal Anesthesia With Articaine and Bupivacaine for Outpatient Lower Limb Surgery","status":"COMPLETED","sponsor":"Reinier de Graaf Groep","startDate":"2006-05","conditions":"Spinal Anesthesia","enrollment":80}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":16,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"spinal administration of articaine","genericName":"spinal administration of articaine","companyName":"Reinier de Graaf Groep","companyId":"reinier-de-graaf-groep","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Articaine is a local anesthetic that blocks sodium channels in nerve fibers when administered into the spinal canal, preventing pain signal transmission. Used for Spinal anesthesia for surgical procedures.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}