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Sevoflurane+Nitrous oxide
Sevoflurane+Nitrous oxide is a General anesthetic (volatile anesthetic + inhalational anesthetic) Small molecule drug developed by Huazhong University of Science and Technology. It is currently FDA-approved for Induction and maintenance of general anesthesia for surgical procedures, Anesthesia for diagnostic procedures requiring sedation.
Sevoflurane and nitrous oxide are volatile anesthetic agents that depress the central nervous system to produce unconsciousness and analgesia for surgical procedures.
Sevoflurane is a small molecule used in medical settings, specifically studied for conditions such as delirium and substance-related disorders. Nitrous oxide, also known as dinitrogen monoxide, is a small molecule used in combination with sevoflurane for various medical interventions, including the prevention of emergence delirium in children.
At a glance
| Generic name | Sevoflurane+Nitrous oxide |
|---|---|
| Sponsor | Huazhong University of Science and Technology |
| Drug class | General anesthetic (volatile anesthetic + inhalational anesthetic) |
| Target | GABA receptors, NMDA receptors |
| Modality | Small molecule |
| Therapeutic area | Anesthesiology |
| Phase | FDA-approved |
Mechanism of action
Sevoflurane is a volatile halogenated ether that enhances inhibitory GABA receptor signaling and inhibits excitatory NMDA receptors, while nitrous oxide acts primarily as an NMDA receptor antagonist. Together, they produce rapid induction and maintenance of general anesthesia with analgesic properties, allowing for controlled sedation during surgical and diagnostic procedures.
Approved indications
- Induction and maintenance of general anesthesia for surgical procedures
- Anesthesia for diagnostic procedures requiring sedation
Common side effects
- Postoperative nausea and vomiting
- Emergence delirium
- Hepatotoxicity (rare)
- Malignant hyperthermia (rare, genetic predisposition)
- Airway irritation
- Hypotension
- Bradycardia
Key clinical trials
- Anesthesia Induced Brain Cancer Survival (ABC Survival): A Feasibility Study (NA)
- Dental Injury Related To Conventional Direct Laryngoscopy
- Clinical Study of Behavior Problems in Children After Different Anesthesia Methods (PHASE4)
- Comparing Ketamine and Fentanyl in Pediatric Tonsillectomy: Pain Control and Emergence Delirium Outcomes (KVFPT) (PHASE4)
- Effect of Ketorolac on Post Adenotonsillectomy Pain (PHASE4)
- Caudal Anesthesia Versus Local Anesthesia in Hypospadias (NA)
- Effect OF Nitrous Oxide On Acute Pain and Opioid Consumption, and Chronic Pain After Hysterectomy (NA)
- Tracheal Colonization and Outcome After Major Abdominal Cancer Surgery (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Sevoflurane+Nitrous oxide CI brief — competitive landscape report
- Sevoflurane+Nitrous oxide updates RSS · CI watch RSS
- Huazhong University of Science and Technology portfolio CI
Frequently asked questions about Sevoflurane+Nitrous oxide
What is Sevoflurane+Nitrous oxide?
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Related
- Drug class: All General anesthetic (volatile anesthetic + inhalational anesthetic) drugs
- Target: All drugs targeting GABA receptors, NMDA receptors
- Manufacturer: Huazhong University of Science and Technology — full pipeline
- Therapeutic area: All drugs in Anesthesiology
- Indication: Drugs for Induction and maintenance of general anesthesia for surgical procedures
- Indication: Drugs for Anesthesia for diagnostic procedures requiring sedation
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing