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NCT01622335
Effect OF Nitrous Oxide On Acute Pain and Opioid Consumption, and Chronic
NA trial testing Nitrous oxide in Abdominal Hysterectomy (& Wertheim). Withdrawn.
1 December 2022
Quick facts
| Lead sponsor | The Cleveland Clinic |
|---|---|
| Phase | NA |
| Status | Withdrawn |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | triple |
| Primary purpose | supportive care |
| Start date | 1 May 2012 |
| Primary completion | 1 December 2022 |
| Estimated completion | 1 December 2023 |
| Sites | 1 location across Turkey (Türkiye) |
Drugs / interventions tested
- Nitrous oxide (NITROUS OXIDE) — full drug profile →
- General anesthesia with oxygen
Conditions studied
- Abdominal Hysterectomy (& Wertheim) — all drugs for Abdominal Hysterectomy (& Wertheim) →
- Nitrous Oxide — all drugs for Nitrous Oxide →
- General Anesthesia — all drugs for General Anesthesia →
Sponsor
The Cleveland Clinic
Who can join
Adults 18 to 65, female only, with Abdominal Hysterectomy (& Wertheim) or Nitrous Oxide. Patients with the condition only — healthy volunteers not accepted.
What's being measured
Primary outcomes are the specific endpoints the trial is designed to prove or disprove.
-
Nitrous oxide and chronic pain
Time frame: 30 days post operative
The of the effect of 50% N20/50% O2 on post hysterectomy in prevention of chronic pain. -
Nitrous oxide and opioid consumption
Time frame: 4 hours post operative
The effect of 50% N20/50% O2 on post hysterectomy in decrease of opioid consumption.
Sponsor's own description
The study is prospective and double blind. In the clinic, patients undergoing hysterectomy that meet the criteria for inclusion into the study and agreed to participate in the study will be randomized into two groups.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT01622335
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Nitrous oxide
Trials testing the same drug.
- NCT06498908 — Intracervical Balloon Placement With Nitrous Oxide Administration · Phase 3 · withdrawn
- NCT06702631 — Nitrous Oxide Neuroimaging · EARLY_PHASE1 · recruiting
- NCT05383495 — Anxiolysis for Laceration Repair in Children · Phase 3 · recruiting
- NCT05895383 — Self-Adjusted Nitrous Oxide: A Feasibility Study in the Setting of Vasectomy · Phase 4 · recruiting
- NCT05388942 — Virtual Reality Hypnosis Versus Inhaled Nitrous Oxide in Anterior Shoulder Dislocation Reduction: an Open Multicenter Ra · NA · unknown
Other The Cleveland Clinic trials
Trials by the same sponsor.
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- NCT07471464 — Centered Surgery - Preoperative Counseling and Patient Satisfaction · recruiting
- NCT07073963 — Virtual Patient Groups for Sarcoidosis Associated Fatigue · NA · recruiting
- NCT07363343 — Nifedipine and Enalapril vs Nifedipine and Labetalol for the Treatment of Postpartum Hypertension Study · NA · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT01622335 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by The Cleveland Clinic
- Last refreshed: 6 May 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT01622335.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing