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Sevoflurane - Neostigmine 30
This is a combination of sevoflurane (a volatile anesthetic) and neostigmine (a cholinesterase inhibitor) used to maintain anesthesia and reverse neuromuscular blockade.
This is a combination of sevoflurane (a volatile anesthetic) and neostigmine (a cholinesterase inhibitor) used to maintain anesthesia and reverse neuromuscular blockade. Used for General anesthesia maintenance during surgical procedures, Reversal of neuromuscular blockade post-operatively.
At a glance
| Generic name | Sevoflurane - Neostigmine 30 |
|---|---|
| Also known as | Inhalational anesthesia |
| Sponsor | Pontificia Universidade Catolica de Sao Paulo |
| Drug class | Volatile anesthetic with cholinesterase inhibitor |
| Modality | Small molecule |
| Therapeutic area | Anesthesiology |
| Phase | FDA-approved |
Mechanism of action
Sevoflurane is a volatile anesthetic agent that depresses the central nervous system to produce unconsciousness and analgesia during surgery. Neostigmine is an acetylcholinesterase inhibitor that prevents the breakdown of acetylcholine, thereby enhancing neuromuscular transmission and reversing the effects of non-depolarizing neuromuscular blocking agents used during anesthesia.
Approved indications
- General anesthesia maintenance during surgical procedures
- Reversal of neuromuscular blockade post-operatively
Common side effects
- Postoperative nausea and vomiting
- Emergence agitation
- Increased salivation (from neostigmine)
- Bradycardia
- Hypotension
Key clinical trials
- Effects Of Anaesthesia on Intraocular Pressure in Robotic Prostate Surgery (NA)
- Open and Laparoscopic Total Extraperitoneal Repair Under Spinal Anesthesia Versus General Anesthesia (NA)
- Consistency Evaluation of the qCON, qNOX Indices and Bispectral Index (NA)
- Different Doses of Neostigmine for Reversal of Moderate Neuromuscular Blockade in Children (PHASE4)
- Three Different Doses of Neostigmine on the Reversal of Cisatracurium-induced Moderate Neuromuscular Blockade (PHASE4)
- Microaspiration in ERCP
- Ketamine or Neostigmine for Serratus Anterior Plane Block in Modified Radical Mastectomy (NA)
- Different Concentrations of Bupivacaine in Erector Spinae Plane Block in Hip Surgeries (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
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