{"id":"sevoflurane-neostigmine-30","safety":{"commonSideEffects":[{"rate":null,"effect":"Postoperative nausea and vomiting"},{"rate":null,"effect":"Emergence agitation"},{"rate":null,"effect":"Increased salivation (from neostigmine)"},{"rate":null,"effect":"Bradycardia"},{"rate":null,"effect":"Hypotension"}]},"_chembl":{"chemblId":"CHEMBL278020","moleculeType":"Small molecule","molecularWeight":"223.30"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Sevoflurane is a volatile anesthetic agent that depresses the central nervous system to produce unconsciousness and analgesia during surgery. Neostigmine is an acetylcholinesterase inhibitor that prevents the breakdown of acetylcholine, thereby enhancing neuromuscular transmission and reversing the effects of non-depolarizing neuromuscular blocking agents used during anesthesia.","oneSentence":"This is a combination of sevoflurane (a volatile anesthetic) and neostigmine (a cholinesterase inhibitor) used to maintain anesthesia and reverse neuromuscular blockade.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T00:07:39.811Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"General anesthesia maintenance during surgical procedures"},{"name":"Reversal of neuromuscular blockade post-operatively"}]},"trialDetails":[{"nctId":"NCT07033442","phase":"NA","title":"Effects Of Anaesthesia on Intraocular Pressure in Robotic Prostate Surgery","status":"COMPLETED","sponsor":"Ataturk Training and Research Hospital","startDate":"2015-07-23","conditions":"Anaesthesia, Intraocular Pressure, Trendelenburg Position","enrollment":60},{"nctId":"NCT05837013","phase":"NA","title":"Open and Laparoscopic Total Extraperitoneal Repair Under Spinal Anesthesia Versus General Anesthesia","status":"COMPLETED","sponsor":"Konya City Hospital","startDate":"2023-09-20","conditions":"Pain, Postoperative, Postoperative Complications, Inguinal Hernia","enrollment":34},{"nctId":"NCT04562181","phase":"NA","title":"Consistency Evaluation of the qCON, qNOX Indices and Bispectral Index","status":"COMPLETED","sponsor":"China Medical University, China","startDate":"2020-09-30","conditions":"Anesthesia Monitor, Electroencephalography, Sleep","enrollment":30},{"nctId":"NCT05053594","phase":"PHASE4","title":"Different Doses of Neostigmine for Reversal of Moderate Neuromuscular Blockade in Children","status":"UNKNOWN","sponsor":"Pontificia Universidade Catolica de Sao Paulo","startDate":"2021-10-01","conditions":"Neuromuscular Blockade, Neuromuscular Block, Residual, Neuromuscular Block Prolonged","enrollment":60},{"nctId":"NCT05037006","phase":"PHASE4","title":"Three Different Doses of Neostigmine on the Reversal of Cisatracurium-induced Moderate Neuromuscular Blockade","status":"UNKNOWN","sponsor":"Pontificia Universidade Catolica de Sao Paulo","startDate":"2021-10-01","conditions":"Neuromuscular Blockade, Neuromuscular Blockade, Residual","enrollment":90},{"nctId":"NCT04831489","phase":"","title":"Microaspiration in ERCP","status":"UNKNOWN","sponsor":"Theodor Bilharz Research Institute","startDate":"2021-04-01","conditions":"Pulmonary Microaspiration","enrollment":50},{"nctId":"NCT04544228","phase":"NA","title":"Ketamine or Neostigmine for Serratus Anterior Plane Block in Modified Radical Mastectomy","status":"COMPLETED","sponsor":"Cairo University","startDate":"2020-09-05","conditions":"Postoperative Pain","enrollment":90},{"nctId":"NCT04442750","phase":"NA","title":"Different Concentrations of Bupivacaine in Erector Spinae Plane Block in Hip Surgeries","status":"UNKNOWN","sponsor":"Cairo University","startDate":"2020-06-22","conditions":"Postoperative Pain","enrollment":100},{"nctId":"NCT03420937","phase":"PHASE4","title":"Deep Neuromuscular Block During General Anaesthesia in Robotic Surgery","status":"COMPLETED","sponsor":"University Hospital Olomouc","startDate":"2016-06","conditions":"Observation of Neuromuscular Block, Complication of Ventilation Therapy, Postoperative Recovery","enrollment":138},{"nctId":"NCT03137290","phase":"NA","title":"Comparing Reversal With Neostigmine and Sugammadex in Paediatric","status":"COMPLETED","sponsor":"Universiti Sains Malaysia","startDate":"2014-12-01","conditions":"Neuromuscular Blockade","enrollment":80},{"nctId":"NCT02698969","phase":"PHASE4","title":"Recovery of Muscle Function After Deep Neuromuscular Block by Means of Diaphragm Ultrasonography","status":"UNKNOWN","sponsor":"University of Florence","startDate":"2014-11","conditions":"Post-operative Residual Curarization","enrollment":58},{"nctId":"NCT01718236","phase":"PHASE4","title":"Modern Myorelaxation Procedure and Reversal of Neuromuscular Blockade With General Anesthesia for Caesarean Section","status":"COMPLETED","sponsor":"Brno University Hospital","startDate":"2012-09","conditions":"Caesarean Section, Pregnancy","enrollment":500},{"nctId":"NCT02513693","phase":"PHASE4","title":"Deep Neuromuscular Blockade During Robotic Radical Prostatectomy","status":"UNKNOWN","sponsor":"Palacky University","startDate":"2015-07","conditions":"Neuromuscular Blockade","enrollment":80},{"nctId":"NCT02360982","phase":"","title":"The Comparison of Incidence and Risk Factors of Postoperative Delirium in Elderly Patients After Lower Extremity Surgery","status":"COMPLETED","sponsor":"Cukurova University","startDate":"2012-03","conditions":"Postoperative Delirium","enrollment":120}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Inhalational anesthesia"],"phase":"marketed","status":"active","brandName":"Sevoflurane - Neostigmine 30","genericName":"Sevoflurane - Neostigmine 30","companyName":"Pontificia Universidade Catolica de Sao Paulo","companyId":"pontificia-universidade-catolica-de-sao-paulo","modality":"Small molecule","firstApprovalDate":"","aiSummary":"This is a combination of sevoflurane (a volatile anesthetic) and neostigmine (a cholinesterase inhibitor) used to maintain anesthesia and reverse neuromuscular blockade. Used for General anesthesia maintenance during surgical procedures, Reversal of neuromuscular blockade post-operatively.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}