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Three Different Doses of Neostigmine on the Reversal of Cisatracurium-induced Moderate Neuromuscular Blockade
The aim of the present study will be to evaluate by means of a prospective randomized clinical trial, the time required for the reversal of moderate neuromuscular blockade (NMB) (Train-of-four count = 3; TOFc 3) to Train-of-four ratio (TOFr) \> 0.9 and TOFr = 1.0 after administration of different doses of neostigmine (30, 50 and 70 mcg/kg) in patients undergoing general anesthesia with propofol or sevoflurane. In addition, the probability of NMB reversal in less than 10 minutes or 15 minutes after neostigmine administration will be registered.
Details
| Lead sponsor | Pontificia Universidade Catolica de Sao Paulo |
|---|---|
| Phase | PHASE4 |
| Status | UNKNOWN |
| Enrolment | 90 |
| Start date | Fri Oct 01 2021 00:00:00 GMT+0000 (Coordinated Universal Time) |
| Completion | Mon Dec 20 2021 00:00:00 GMT+0000 (Coordinated Universal Time) |
Conditions
- Neuromuscular Blockade
- Neuromuscular Blockade, Residual
Interventions
- Sevoflurane - Neostigmine 30
- Sevoflurane - Neostigmine 50
- Sevoflurane - Neostigmine 70
- TIVA - Neostigmine 30
- TIVA - Neostigmine 50
- TIVA - Neostigmine 70
Countries
Brazil