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S-1 [Tegafur/Oteracil/gimeracil]
S-1 [Tegafur/Oteracil/gimeracil] is a Antineoplastic agent Small molecule drug developed by AstraZeneca. It is currently in Phase 3 development for Advanced gastric cancer, Pancreatic cancer.
S-1 works by inhibiting thymidylate synthase, which is necessary for DNA synthesis, thereby inducing apoptosis in cancer cells.
S-1 works by inhibiting thymidylate synthase, which is necessary for DNA synthesis, thereby inducing apoptosis in cancer cells. Used for Advanced gastric cancer, Pancreatic cancer.
At a glance
| Generic name | S-1 [Tegafur/Oteracil/gimeracil] |
|---|---|
| Sponsor | AstraZeneca |
| Drug class | Antineoplastic agent |
| Target | Thymidylate synthase |
| Modality | Small molecule |
| Therapeutic area | Oncology |
| Phase | Phase 3 |
Mechanism of action
S-1 is a combination of tegafur, a prodrug of 5-fluorouracil, oteracil, which inhibits the degradation of 5-fluorouracil, and gimeracil, which enhances the concentration of 5-fluorouracil. This combination allows for a higher dose of 5-fluorouracil to be administered, while minimizing gastrointestinal toxicity.
Approved indications
- Advanced gastric cancer
- Pancreatic cancer
Common side effects
- Diarrhea
- Nausea
- Vomiting
- Fatigue
- Anemia
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- S-1 [Tegafur/Oteracil/gimeracil] CI brief — competitive landscape report
- S-1 [Tegafur/Oteracil/gimeracil] updates RSS · CI watch RSS
- AstraZeneca portfolio CI
Frequently asked questions about S-1 [Tegafur/Oteracil/gimeracil]
What is S-1 [Tegafur/Oteracil/gimeracil]?
How does S-1 [Tegafur/Oteracil/gimeracil] work?
What is S-1 [Tegafur/Oteracil/gimeracil] used for?
Who makes S-1 [Tegafur/Oteracil/gimeracil]?
What drug class is S-1 [Tegafur/Oteracil/gimeracil] in?
What development phase is S-1 [Tegafur/Oteracil/gimeracil] in?
What are the side effects of S-1 [Tegafur/Oteracil/gimeracil]?
What does S-1 [Tegafur/Oteracil/gimeracil] target?
Related
- Drug class: All Antineoplastic agent drugs
- Target: All drugs targeting Thymidylate synthase
- Manufacturer: AstraZeneca — full pipeline
- Therapeutic area: All drugs in Oncology
- Indication: Drugs for Advanced gastric cancer
- Indication: Drugs for Pancreatic cancer
- Compare: S-1 [Tegafur/Oteracil/gimeracil] vs similar drugs
- Pricing: S-1 [Tegafur/Oteracil/gimeracil] cost, discount & access