What are Antineoplastic agent drugs?

Antineoplastic agent drugs are pharmacologic agents that share a common mechanism (typically targeting DNA and topoisomerase II). 1 are currently marketed, with 7 more in clinical development.

What are the marketed Antineoplastic agent drugs?

Marketed Antineoplastic agent drugs include Liposomal doxorubicin hydrochloride.

Antineoplastic agent

1 marketed 3 in Phase 3 4 in Phase 2

This page covers all Antineoplastic agent drugs tracked by Drug Landscape: marketed products and active clinical-stage compounds, targeting DNA and topoisomerase II, DNA, Thymidylate synthase.

Targets

DNA and topoisomerase II · DNA · Thymidylate synthase · Thymidylate synthase, Dihydrofolate reductase, Glycinamide ribonucleotide formyltransferase

Marketed (1)

Liposomal doxorubicin hydrochloride · Cephalon, Inc. · Oncology

Phase 3 pipeline (3)

TS-1 and cisplatin · Taiho Pharmaceutical Co., Ltd. · Oncology
TS-1 is a prodrug that is converted into 5-fluorouracil (5-FU) in the body, which is then incorporated into DNA and RNA, interfering with DNA replication and transcription, and cisplatin is a platinum-based chemotherapy drug that works by cross-linking DNA, thereby inhibiting DNA replication and transcription.
S-1 [Tegafur/Oteracil/gimeracil] · AstraZeneca · Oncology
S-1 works by inhibiting thymidylate synthase, which is necessary for DNA synthesis, thereby inducing apoptosis in cancer cells.
Pemetrexed + Cisplatin /Carboplatin · Jiangsu Hansoh Pharmaceutical Co., Ltd. · Oncology
Pemetrexed is a folate antagonist that inhibits thymidylate synthase, dihydrofolate reductase, and glycinamide ribonucleotide formyltransferase, leading to cell death in rapidly dividing cancer cells. Cisplatin and Carboplatin are platinum-based chemotherapeutic agents that induce DNA crosslinks, causing cell death.

Phase 2 pipeline (4)

Capecitabine plus temozolomide VS Capecitabine · Asan Medical Center · Oncology
Capecitabine is a prodrug that is converted into 5-fluorouracil, which interferes with DNA synthesis, thereby inhibiting cancer cell growth. Temozolomide works by methylating DNA, which triggers cell death in rapidly dividing cancer cells.
Fluoropyrimidine- and Platinum-containing Therapy · Beijing Biostar Pharmaceuticals Co., Ltd. · Oncology
Fluoropyrimidine- and Platinum-containing Therapy works by interfering with DNA replication and transcription, ultimately leading to cell death.
Fluoropyrimidine plus leucovorin · Seattle Project Corporation · Oncology
Inhibits thymidylate synthase
Folotyn and Leucovorin · Acrotech Biopharma Inc. · Oncology
Folotyn is a pegylated form of calicheamicin, a potent antitumor antibiotic that binds to DNA and inhibits RNA synthesis, while Leucovorin is a folate analog that inhibits dihydrofolate reductase, thereby increasing the effectiveness of folate-dependent drugs.