{"id":"s-1-tegafur-oteracil-gimeracil","safety":{"commonSideEffects":[{"rate":"30-50%","effect":"Diarrhea"},{"rate":"20-40%","effect":"Nausea"},{"rate":"10-30%","effect":"Vomiting"},{"rate":"10-20%","effect":"Fatigue"},{"rate":"5-15%","effect":"Anemia"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"S-1 is a combination of tegafur, a prodrug of 5-fluorouracil, oteracil, which inhibits the degradation of 5-fluorouracil, and gimeracil, which enhances the concentration of 5-fluorouracil. This combination allows for a higher dose of 5-fluorouracil to be administered, while minimizing gastrointestinal toxicity.","oneSentence":"S-1 works by inhibiting thymidylate synthase, which is necessary for DNA synthesis, thereby inducing apoptosis in cancer cells.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:33:08.244Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Advanced gastric cancer"},{"name":"Pancreatic cancer"}]},"trialDetails":[],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":90626,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"S-1 [Tegafur/Oteracil/gimeracil]","genericName":"S-1 [Tegafur/Oteracil/gimeracil]","companyName":"AstraZeneca","companyId":"astrazeneca","modality":"Small molecule","firstApprovalDate":"","aiSummary":"S-1 works by inhibiting thymidylate synthase, which is necessary for DNA synthesis, thereby inducing apoptosis in cancer cells. Used for Advanced gastric cancer, Pancreatic cancer.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":false,"score":3}}