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Ropivacaine instillation
Ropivacaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and propagation of action potentials.
Ropivacaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and propagation of action potentials. Used for Postoperative pain management via surgical site instillation, Intraoperative local anesthesia during surgical procedures.
At a glance
| Generic name | Ropivacaine instillation |
|---|---|
| Also known as | Ropivacaine, Instillation |
| Sponsor | San Gerardo Hospital |
| Drug class | Local anesthetic (amide) |
| Target | Voltage-gated sodium channels |
| Modality | Small molecule |
| Therapeutic area | Anesthesia / Pain Management |
| Phase | Phase 3 |
Mechanism of action
Ropivacaine is an amide-type local anesthetic that reversibly inhibits sodium influx into nerve fibers, thereby preventing depolarization and nerve impulse transmission. When instilled into surgical or procedural sites, it provides localized anesthesia and analgesia by blocking sensory and motor nerve conduction in the area of administration. This mechanism allows for pain control during and after surgical procedures without systemic anesthesia.
Approved indications
- Postoperative pain management via surgical site instillation
- Intraoperative local anesthesia during surgical procedures
Common side effects
- Local tissue irritation or inflammation
- Systemic toxicity (if absorbed in high concentrations)
- Allergic reactions
- Transient paresthesia
Key clinical trials
- The Impact of Intrapleural Block on Postoperative Pain Caused by Drainage Tubes After Thoracoscopic Surgery (NA)
- Total Knee Arthroplasty Infiltration Study for Postoperative Analgesia (PHASE2)
- ZYNRELEF® for Postoperative Analgesia After Laparoscopic Sleeve Gastrectomy (PHASE4)
- Nerve Blocks vs Local Injections for Post-op Pain Prevention in Laparoscopic Cholecystectomy in Children (NA)
- Efficacy of Ropivacaine Continuous Wound Instillation Versus Single Shot After Spine Fusion Surgery (PHASE4)
- Evaluation of the Interest of the Instillation of Saline Intraperitoneally (INSI ) Versus Instillation of Naropin the Surgical Site Versus Lung Recruitment Maneuvers ( PVM ) in the Management of Pain After Laparoscopic Cholecystectomy in Ambulatory Care (PHASE3)
- Comparison of Administation Routes of Ropivacaine (PHASE4)
- Local Analgesia to Prevent Pain in Patient Undergoing Removal of the Uterus Through Vaginal Route (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Ropivacaine instillation CI brief — competitive landscape report
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- San Gerardo Hospital portfolio CI