{"id":"ropivacaine-instillation","safety":{"commonSideEffects":[{"rate":null,"effect":"Local tissue irritation or inflammation"},{"rate":null,"effect":"Systemic toxicity (if absorbed in high concentrations)"},{"rate":null,"effect":"Allergic reactions"},{"rate":null,"effect":"Transient paresthesia"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"anthropic-haiku","explanation":"Ropivacaine is an amide-type local anesthetic that reversibly inhibits sodium influx into nerve fibers, thereby preventing depolarization and nerve impulse transmission. When instilled into surgical or procedural sites, it provides localized anesthesia and analgesia by blocking sensory and motor nerve conduction in the area of administration. This mechanism allows for pain control during and after surgical procedures without systemic anesthesia.","oneSentence":"Ropivacaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and propagation of action potentials.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:32:47.679Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Postoperative pain management via surgical site instillation"},{"name":"Intraoperative local anesthesia during surgical procedures"}]},"trialDetails":[{"nctId":"NCT07294755","phase":"NA","title":"The Impact of Intrapleural Block on Postoperative Pain Caused by Drainage Tubes After Thoracoscopic Surgery","status":"NOT_YET_RECRUITING","sponsor":"Chinese PLA General Hospital","startDate":"2026-04-20","conditions":"Postoperative Analgesia","enrollment":300},{"nctId":"NCT03015532","phase":"PHASE2","title":"Total Knee Arthroplasty Infiltration Study for Postoperative 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Postoperative","enrollment":48},{"nctId":"NCT03265223","phase":"PHASE4","title":"Ropivacaine Use Intraincisionally Versus Intraperitoneally for Post-Laparoscopic Cholecystectomy Pain","status":"COMPLETED","sponsor":"Jawaharlal Nehru Medical College","startDate":"2014-04-01","conditions":"Ropivacaine, Laparoscopic Cholecystectomy, Pain","enrollment":353},{"nctId":"NCT02449720","phase":"PHASE4","title":"Intraperitoneal Local Anaesthetic in Bowel Surgery","status":"COMPLETED","sponsor":"Royal Adelaide Hospital","startDate":"2015-05","conditions":"Colorectal Disorders","enrollment":86},{"nctId":"NCT00130091","phase":"PHASE2","title":"The Addition of Clonidine to 0.2% Ropivacaine for Wound Instillation After Minor Lower Abdominal Surgery in Children","status":"COMPLETED","sponsor":"Children's Hospital of Eastern Ontario","startDate":"2009-09","conditions":"Hernia, Inguinal, Hydrocele","enrollment":120},{"nctId":"NCT01074229","phase":"NA","title":"Transversus Abdominis Plane (TAP) Block 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Cholecystectomy","enrollment":60},{"nctId":"NCT00801528","phase":"PHASE4","title":"Diclofenac vs. Ropivacaine for Cesarean Section","status":"COMPLETED","sponsor":"Meir Medical Center","startDate":"2008-04","conditions":"Cesarean Section","enrollment":75}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":14,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Ropivacaine","Instillation"],"phase":"phase_3","status":"active","brandName":"Ropivacaine instillation","genericName":"Ropivacaine instillation","companyName":"San Gerardo Hospital","companyId":"san-gerardo-hospital","modality":"Small 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Used for Postoperative pain management via surgical site instillation, Intraoperative local anesthesia during surgical procedures.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}