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Resuscitation (Voluven)
Voluven is a hydroxyethyl starch (HES) plasma volume expander that increases and maintains circulating blood volume in patients with acute blood loss.
Voluven is a hydroxyethyl starch (HES) plasma volume expander that increases and maintains circulating blood volume in patients with acute blood loss. Used for Acute blood loss and hypovolemia requiring volume replacement.
At a glance
| Generic name | Resuscitation (Voluven) |
|---|---|
| Sponsor | Universidad Nacional de La Plata |
| Drug class | Colloid plasma volume expander |
| Modality | Small molecule |
| Therapeutic area | Critical Care / Emergency Medicine |
| Phase | Phase 3 |
Mechanism of action
Voluven works as a colloid solution that remains in the intravascular space longer than crystalloid fluids, providing sustained hemodynamic support and oxygen delivery to tissues. It is used during acute hemorrhage or hypovolemia to restore circulating volume and maintain blood pressure until definitive treatment or blood transfusion can be administered.
Approved indications
- Acute blood loss and hypovolemia requiring volume replacement
Common side effects
- Coagulopathy / increased bleeding risk
- Acute kidney injury
- Hyperchloremic acidosis
- Anaphylactic reactions
Key clinical trials
- Hydroxyethyl Starch Versus Crystalloid and Postoperative Major Adverse Kidney Complications (PHASE4)
- Optimizing Fluid Resuscitation in Adults With Major Burns: A Randomized Trial of Burn Navigator™ Versus Parkland Formula (PHASE4)
- The Potential Therapeutic Role of Hydroxyethyl Starch and Hydrocortisone in Acute Aluminum Phosphide Poisoning (NA)
- Impact of Acute Normovolemic Hemodilution on Blood Viscosity (NA)
- Comparing Human Albumin Versus Hydroxyethylstarch in Renal Transplant Recipients (NA)
- Goal-Directed Intraoperative Fluid Management Using FloTrac© Monitoring in High-Risk Neurosurgical Patients (NA)
- Starch or Saline After Cardiac Surgery (NA)
- Fluid Resuscitation With Hydroxyethyl Starch 130/0.4 in Trauma Patients (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Resuscitation (Voluven) CI brief — competitive landscape report
- Resuscitation (Voluven) updates RSS · CI watch RSS
- Universidad Nacional de La Plata portfolio CI