{"id":"resuscitation-voluven","safety":{"commonSideEffects":[{"rate":null,"effect":"Coagulopathy / increased bleeding risk"},{"rate":null,"effect":"Acute kidney injury"},{"rate":null,"effect":"Hyperchloremic acidosis"},{"rate":null,"effect":"Anaphylactic reactions"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"anthropic-haiku","explanation":"Voluven works as a colloid solution that remains in the intravascular space longer than crystalloid fluids, providing sustained hemodynamic support and oxygen delivery to tissues. It is used during acute hemorrhage or hypovolemia to restore circulating volume and maintain blood pressure until definitive treatment or blood transfusion can be administered.","oneSentence":"Voluven is a hydroxyethyl starch (HES) plasma volume expander that increases and maintains circulating blood volume in patients with acute blood loss.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:52:25.014Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acute blood loss and hypovolemia requiring volume replacement"}]},"trialDetails":[{"nctId":"NCT07410988","phase":"PHASE4","title":"Hydroxyethyl Starch Versus Crystalloid and Postoperative Major Adverse Kidney Complications","status":"NOT_YET_RECRUITING","sponsor":"Seoul National University Hospital","startDate":"2026-04-01","conditions":"Cardiac Surgery","enrollment":1292},{"nctId":"NCT07307599","phase":"PHASE4","title":"Optimizing Fluid Resuscitation in Adults With Major Burns: A Randomized Trial of Burn Navigator™ Versus Parkland Formula","status":"NOT_YET_RECRUITING","sponsor":"Alnas Hospital","startDate":"2026-01-01","conditions":"Resuscitation, Burn","enrollment":62},{"nctId":"NCT04465539","phase":"NA","title":"The Potential Therapeutic Role of Hydroxyethyl Starch and Hydrocortisone in Acute Aluminum Phosphide Poisoning","status":"COMPLETED","sponsor":"Tanta University","startDate":"2020-07-15","conditions":"Potential Therapeutic Role","enrollment":60},{"nctId":"NCT03366753","phase":"NA","title":"Impact of Acute Normovolemic Hemodilution on Blood Viscosity","status":"COMPLETED","sponsor":"Konkuk University Medical Center","startDate":"2018-05-02","conditions":"Ischemic Heart Disease, Coronary Artery Disease","enrollment":21},{"nctId":"NCT03306914","phase":"NA","title":"Comparing Human Albumin Versus Hydroxyethylstarch in Renal Transplant Recipients","status":"COMPLETED","sponsor":"Cairo University","startDate":"2017-10-15","conditions":"Anesthesia Morbidity","enrollment":120},{"nctId":"NCT02701582","phase":"NA","title":"Goal-Directed Intraoperative Fluid Management Using FloTrac© Monitoring in High-Risk Neurosurgical Patients","status":"COMPLETED","sponsor":"NYU Langone Health","startDate":"2014-03","conditions":"Intracranial Aneurysm, Brain Edema, Scoliosis","enrollment":66},{"nctId":"NCT00964015","phase":"NA","title":"Starch or Saline After Cardiac Surgery","status":"TERMINATED","sponsor":"London Health Sciences Centre","startDate":"2009-08","conditions":"Coronary Artery Bypass Surgery","enrollment":69},{"nctId":"NCT03486600","phase":"NA","title":"Fluid Resuscitation With Hydroxyethyl Starch 130/0.4 in Trauma Patients","status":"UNKNOWN","sponsor":"Zagazig University","startDate":"2018-04-01","conditions":"Trauma","enrollment":392},{"nctId":"NCT00983281","phase":"","title":"Use of Hextend in Trauma","status":"COMPLETED","sponsor":"University of Miami","startDate":"2008-08","conditions":"Trauma","enrollment":1714},{"nctId":"NCT01319630","phase":"","title":"The Effect of Three Different Fluids(Albumin 5%, Normal Saline, Hydroxyethyl Starch 130 kD) on Microcirculation in Severe Sepsis/Septic Shock Patients","status":"COMPLETED","sponsor":"Mercy Research","startDate":"2011-04","conditions":"Severe Sepsis, Septic Shock, Microcirculation","enrollment":45},{"nctId":"NCT02308371","phase":"NA","title":"PPV to Guide Fluid Management in the PICU","status":"COMPLETED","sponsor":"University of North Carolina, Chapel Hill","startDate":"2014-11","conditions":"Sepsis, Systemic Inflammatory Response Syndrome","enrollment":100},{"nctId":"NCT01763853","phase":"PHASE4","title":"Impact of Fluid Resuscitation Therapy on Pulmonary Edema as Measured by Alveolar Fluid Clearance in Patients With Acute Respiratory Distress Syndrome (ARDS)","status":"UNKNOWN","sponsor":"University Hospital, Clermont-Ferrand","startDate":"2012-12","conditions":"Acute Respiratory Distress Syndrome (ARDS), Hypovolemia, Pulmonary Edema","enrollment":70},{"nctId":"NCT00135473","phase":"PHASE3","title":"Efficacy of Volume Substitution and Insulin Therapy in Severe Sepsis (VISEP Trial)","status":"COMPLETED","sponsor":"SepNet - Critical Care Trials Group","startDate":"2003-04","conditions":"Severe Sepsis, Septic Shock","enrollment":600},{"nctId":"NCT01689506","phase":"PHASE4","title":"Fluid Resuscitation in Patients Suffering From Burns Injury","status":"TERMINATED","sponsor":"Fresenius Kabi","startDate":"2012-12","conditions":"Burns","enrollment":11},{"nctId":"NCT00935168","phase":"PHASE3","title":"Crystalloid Versus Hydroxyethyl Starch Trials","status":"COMPLETED","sponsor":"The George Institute","startDate":"2009-12","conditions":"Intensive Care","enrollment":7000},{"nctId":"NCT00273728","phase":"PHASE4","title":"BaSES Trial: Basel Starch Evaluation in Sepsis","status":"COMPLETED","sponsor":"University Hospital, Basel, Switzerland","startDate":"2005-05","conditions":"Sepsis, Severe Sepsis, Septic Shock","enrollment":231},{"nctId":"NCT00987701","phase":"NA","title":"Perineuraxial Anesthesia Fluid Management and Infant Neurobehaviors","status":"COMPLETED","sponsor":"Nanjing Medical University","startDate":"2009-09","conditions":"Cesarean Section","enrollment":5000},{"nctId":"NCT01012648","phase":"PHASE4","title":"Early Fluid Resuscitation With Balanced HES 130/0.4 [6%] in Severe Burn Injury","status":"UNKNOWN","sponsor":"University of Zurich","startDate":"2009-11","conditions":"Burns","enrollment":48},{"nctId":"NCT00890383","phase":"PHASE4","title":"Colloids in Severe Trauma","status":"COMPLETED","sponsor":"University of the Philippines","startDate":"2009-05","conditions":"Abdominal Hypertension, Abdominal Compartment Syndrome, Severe Trauma","enrollment":50},{"nctId":"NCT00337805","phase":"PHASE2, PHASE3","title":"Double Blind Randomized Trial of Saline vs Pentaspan for Resuscitation After Cardiac Surgery","status":"COMPLETED","sponsor":"McGill University Health Centre/Research Institute of the McGill University Health Centre","startDate":"2004-09","conditions":"Cardiac Surgery","enrollment":240},{"nctId":"NCT00799916","phase":"PHASE3","title":"Saline Solution Versus Voluven®: A Controlled Study of Fluid Resuscitation in Severe Sepsis","status":"COMPLETED","sponsor":"Universidad Nacional de La Plata","startDate":"2006-01","conditions":"Sepsis","enrollment":30}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":23,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Resuscitation (Voluven)","genericName":"Resuscitation (Voluven)","companyName":"Universidad Nacional de La Plata","companyId":"universidad-nacional-de-la-plata","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Voluven is a hydroxyethyl starch (HES) plasma volume expander that increases and maintains circulating blood volume in patients with acute blood loss. Used for Acute blood loss and hypovolemia requiring volume replacement.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}