Short-term Outcomes of Fluid Replacement and Resuscitation Strategy in the Cardiac Surgery Patient: A Randomized, Controlled Trial (SSACS)

NCT00964015 NA TERMINATED

When people undergo major surgery, they require intravenous supplementation of fluids for a number of reasons: * to compensate for no oral intake * to support blood pressure and organ function during and after surgery * to replace lost fluid or blood volume There are a variety of fluid choices doctors have to provide to patients, and it is still not definitively known whether some fluids are better than others in specific situations. This is a particularly interesting question in patients undergoing heart surgery because of the significant volume of fluids used over the entire course of hospitalization, including before the operation, during the operation, and after the operation. There has been some scientific evidence that the use of starch-based fluids (synthetic colloids) leads to better oxygen delivery to the organs with a smaller volume of fluid given, providing for better recovery from surgery. However, there has also been some scientific evidence that the use of these fluids can harm kidney function. Importantly, none of these large-scale studies were carried out specifically in patients undergoing heart surgery. The purpose of this study is to answer the question of whether the use of starch-based fluid in the heart surgery patient makes for a safer and faster recovery, causes kidney dysfunction, or makes no discernable difference.

Details

Lead sponsor	London Health Sciences Centre
Phase	NA
Status	TERMINATED
Enrolment	69
Start date	2009-08
Completion	2012-06

Conditions

• Coronary Artery Bypass Surgery

Interventions

• 6% Hydroxyethyl Starch 130/0.4
• 0.9% Normal Saline

Primary outcomes

• Incidence of acute kidney injury as defined by RIFLE criteria — Short term (in hospital, up to 30 days) and mid-term (2 months)
• Maximum postoperative weight gain — Short-term (in hospital, up to 7 days)

Countries

Canada