Last reviewed · How we verify
Rectal Indomethacin
Rectal Indomethacin is a Nonsteroidal anti-inflammatory drug (NSAID) Small molecule drug developed by Moti Lal Nehru Medical College. It is currently FDA-approved for Rheumatoid arthritis, Osteoarthritis, Ankylosing spondylitis. Also known as: Indocin, NSAIDs, NSAIDS, Indomethacin Suppositories.
Indomethacin is a nonsteroidal anti-inflammatory drug (NSAID) that inhibits cyclooxygenase (COX) enzymes to reduce prostaglandin synthesis, thereby decreasing inflammation, pain, and fever.
Rectal Indomethacin is a small molecule that acts as a cyclooxygenase inhibitor. It has been studied in clinical trials for various conditions, including pancreatitis and papillomavirus infections, and is administered via rectal route.
At a glance
| Generic name | Rectal Indomethacin |
|---|---|
| Also known as | Indocin, NSAIDs, NSAIDS, Indomethacin Suppositories |
| Sponsor | Moti Lal Nehru Medical College |
| Drug class | Nonsteroidal anti-inflammatory drug (NSAID) |
| Target | Cyclooxygenase-1 (COX-1) and Cyclooxygenase-2 (COX-2) |
| Modality | Small molecule |
| Therapeutic area | Rheumatology, Pain Management, Neurology |
| Phase | FDA-approved |
Mechanism of action
Indomethacin blocks both COX-1 and COX-2 enzymes, which are responsible for converting arachidonic acid into prostaglandins. By reducing prostaglandin levels, the drug suppresses inflammatory mediators and provides analgesic and antipyretic effects. The rectal formulation allows for local and systemic absorption, making it useful for patients unable to take oral medication.
Approved indications
- Rheumatoid arthritis
- Osteoarthritis
- Ankylosing spondylitis
- Acute pain and inflammation
- Patent ductus arteriosus (PDA) closure in premature infants
- Migraine headaches
Common side effects
- Gastrointestinal irritation or ulceration
- Dyspepsia
- Headache
- Dizziness
- Rectal irritation (rectal formulation)
- Nausea
- Renal impairment
- Cardiovascular events (with chronic use)
Key clinical trials
- Prophylactic PS Placement to Prevent Pancreatitis After Endoscopic Transpapillary GPC for Cholelithiasis With Concomitant Choledocholithiasis (NA)
- Study Comparing Transobturator Cystocele vs. Anterior Vaginal RepairS (NA)
- Rectal Indomethacin vs Intravenous Ketorolac (PHASE4)
- E7 TCR T Cells for Human Papillomavirus-Associated Cancers (PHASE1, PHASE2)
- Cold Water Irrigation Therapy as an Adjunct to Indomethacin for Post-Endoscopic Retrograde Cholangiopancreatography(ERCP) Pancreatitis (NA)
- Indian National Study to Assess Incidence and Severity of Post-ERCP Pancreatitis After Following SOP
- Rectal Indomethacin and Oral Tacrolimus Versus Combination to Prevent Post-ERCP Pancreatitis (PHASE3)
- Rectal NSAIDs With/Without PD Stent for PEP Prevention (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Rectal Indomethacin CI brief — competitive landscape report
- Rectal Indomethacin updates RSS · CI watch RSS
- Moti Lal Nehru Medical College portfolio CI
Frequently asked questions about Rectal Indomethacin
What is Rectal Indomethacin?
How does Rectal Indomethacin work?
What is Rectal Indomethacin used for?
Who makes Rectal Indomethacin?
Is Rectal Indomethacin also known as anything else?
What drug class is Rectal Indomethacin in?
What development phase is Rectal Indomethacin in?
What are the side effects of Rectal Indomethacin?
What does Rectal Indomethacin target?
Related
- Drug class: All Nonsteroidal anti-inflammatory drug (NSAID) drugs
- Target: All drugs targeting Cyclooxygenase-1 (COX-1) and Cyclooxygenase-2 (COX-2)
- Manufacturer: Moti Lal Nehru Medical College — full pipeline
- Therapeutic area: All drugs in Rheumatology, Pain Management, Neurology
- Indication: Drugs for Rheumatoid arthritis
- Indication: Drugs for Osteoarthritis
- Indication: Drugs for Ankylosing spondylitis
- Also known as: Indocin, NSAIDs, NSAIDS, Indomethacin Suppositories
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing