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NCT07330284
Adjunctive Cold Water Irrigation Added to Rectal Indomethacin for Prevention of Post- Endoscopic Retrograde Cholangiopancreatography (ERCP) Pancreatitis
NA trial testing Cold water in Pancreatitis in 950 participants. Currently enrolling.
1 July 2029
Quick facts
| Lead sponsor | University of Kansas Medical Center |
|---|---|
| Phase | NA |
| Status | Recruiting now |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | double |
| Primary purpose | prevention |
| Enrollment | 950 |
| Start date | 5 December 2025 |
| Primary completion | 1 July 2029 |
| Estimated completion | 1 December 2029 |
| Sites | 1 location across United States |
Drugs / interventions tested
- Cold water — full drug profile →
- Warm water
Conditions studied
- Pancreatitis — all drugs for Pancreatitis →
- ERCP Surgery — all drugs for ERCP Surgery →
Sponsor
University of Kansas Medical Center
Who can join
20 and older, any sex, with Pancreatitis or ERCP Surgery. Patients with the condition only — healthy volunteers not accepted.
What's being measured
Primary outcomes are the specific endpoints the trial is designed to prove or disprove.
-
Incidence of Post-ERCP Pancreatitis (PEP) between the cold water and control groups
Time frame: approximately 24-36 months.
The incidence of post-ERCP pancreatitis (PEP) is defined according to established consensus criteria as new or worsened abdominal pain persisting for at least 24 hours after ERCP, accompanied by serum amylase or lipase levels ≥3 times the upper limit of normal at approximately 24 hours post-procedure, and necessitating hospital admission or prolongation of planned observation.
Sponsor's own description
This study is designed to learn whether rinsing the papilla with cold water at the end of an ERCP procedure, in addition to standard medicine, can help lower the chance of developing pancreatitis, which is the most common major complication after ERCP.
Publications & conference data
No peer-reviewed publications indexed yet for this trial.
Verify or expand the search:
- PubMed search for NCT07330284
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Cold water
Trials testing the same drug.
- NCT04464005 — Comparison Between Pads With Cold Solution of Magnesium Sulfate or Cold Water Postpartum Perineal Pain and Healing · Phase 4 · unknown
Other recruiting trials for Pancreatitis
Currently open trials in the same condition.
- NCT07083063 — Precise Endoscopic Application of Nitroglycerin in Preventing Post-ERCP Pancreatitis · Phase 4 · recruiting
- NCT07262957 — Preventing Postoperative Complications in Patients Undergoing High-risk Pancreatoduodenectomy With a Bundle Approach Inc · Phase 4 · recruiting
- NCT07012772 — COMBO Endoscopy Oropharyngeal Airway in Sedated Endoscopic Retrograde Cholangiopancreatography for Patients · Phase 2 · recruiting
- NCT07051980 — Feasibility and Safety of Supraglottic Oxygen Delivery Via an Endotracheal Tube for Non-intubated ERCP Anesthesia: A Two · Phase 2 · recruiting
- NCT07071441 — Indomethacin vs Diclofenac for Preventing PEP · NA · recruiting
Other University of Kansas Medical Center trials
Trials by the same sponsor.
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- NCT07463755 — Low-Fidelity Driving Simulator Training in Parkinson's Disease. · NA · not yet recruiting
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT07330284 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University of Kansas Medical Center
- Last refreshed: 4 May 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT07330284.
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