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propofol targel controlled infusion
Propofol is a short-acting intravenous anesthetic that enhances inhibitory GABA neurotransmission in the central nervous system to produce sedation and anesthesia.
Propofol is a short-acting intravenous anesthetic that enhances inhibitory GABA neurotransmission in the central nervous system to produce sedation and anesthesia. Used for Induction and maintenance of general anesthesia, Sedation in intensive care units, Sedation for diagnostic and therapeutic procedures.
At a glance
| Generic name | propofol targel controlled infusion |
|---|---|
| Also known as | propofol TCI |
| Sponsor | Universidad del Desarrollo |
| Drug class | GABA-A receptor positive allosteric modulator |
| Target | GABA-A receptor |
| Modality | Small molecule |
| Therapeutic area | Anesthesia |
| Phase | FDA-approved |
Mechanism of action
Propofol acts as a positive allosteric modulator of GABA-A receptors, increasing chloride ion influx and neuronal hyperpolarization. This results in rapid onset of unconsciousness and sedation. Target-controlled infusion (TCI) is a delivery method that uses pharmacokinetic modeling to maintain a constant plasma or effect-site concentration of propofol, allowing for more precise anesthetic control.
Approved indications
- Induction and maintenance of general anesthesia
- Sedation in intensive care units
- Sedation for diagnostic and therapeutic procedures
Common side effects
- Hypotension
- Respiratory depression
- Bradycardia
- Injection site pain
- Apnea
- Propofol infusion syndrome (with prolonged use)
Key clinical trials
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- propofol targel controlled infusion CI brief — competitive landscape report
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