Neuronal Inertia´s Effect on Pharmacological Behavior Representation of Propofol (INERTIA)

NCT01962285 Phase 4 COMPLETED

Loss and recovery of consciousness during propofol anesthesia seem to be mediated by different mechanisms beyond the actual effect-site concentration of anesthetic drug. This eventual difference between dose response curves for loss of consciousness (LOC) and for recovery of consciousness (ROC) beyond hysteresis has received the name of neuronal inertia. We performed a volunteer-study comparing LOC and ROC curves during a slow, steady-sate, stepped target controlled infusion of Propofol. Our hypothesis is that, at steady-state conditions between plasma an effect-site concentration, there is still going to exist a difference between LOC and ROC, demonstrating the existence of neuronal inertia.

Details

Lead sponsor	Universidad del Desarrollo
Phase	Phase 4
Status	COMPLETED
Enrolment	14
Start date	2013-08
Completion	2013-10

Conditions

• General Anesthesia
• Propofol Pharmacodynamics
• Propofol Target Controlled Infusion
• Loss of Consciousness and Recovery of Consciousness
• Propofol Plasma Concentration

Interventions

• propofol targel controlled infusion

Primary outcomes

• plasma-equilibrated effect site concentration of propofol at LOC and ROC (mcg/ml) — 2 hours (during slow steady-state concentration propofol infusion)
  determination of plasma concentration of PROPOFOL at the time of Loss of Consciousness and the time of recovery of consciousness during the 7-minute step infusion. Provided it is a slow increasing infusion we assume a pseudo-equilibrium state between plasma and effect site. the existence of a difference between these two values will support the hypothesis of neuronal inertia

Countries

Chile