{"id":"propofol-targel-controlled-infusion","safety":{"commonSideEffects":[{"rate":"20-30","effect":"Hypotension"},{"rate":"10-20","effect":"Respiratory depression"},{"rate":"5-15","effect":"Bradycardia"},{"rate":"10-20","effect":"Injection site pain"},{"rate":"5-10","effect":"Apnea"},{"rate":"<1","effect":"Propofol infusion syndrome (with prolonged use)"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Propofol acts as a positive allosteric modulator of GABA-A receptors, increasing chloride ion influx and neuronal hyperpolarization. This results in rapid onset of unconsciousness and sedation. Target-controlled infusion (TCI) is a delivery method that uses pharmacokinetic modeling to maintain a constant plasma or effect-site concentration of propofol, allowing for more precise anesthetic control.","oneSentence":"Propofol is a short-acting intravenous anesthetic that enhances inhibitory GABA neurotransmission in the central nervous system to produce sedation and anesthesia.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:03:13.977Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Induction and maintenance of general anesthesia"},{"name":"Sedation in intensive care units"},{"name":"Sedation for diagnostic and therapeutic procedures"}]},"trialDetails":[{"nctId":"NCT01962285","phase":"PHASE4","title":"Neuronal Inertia in Propofol Anesthesia","status":"COMPLETED","sponsor":"Universidad del Desarrollo","startDate":"2013-08","conditions":"General Anesthesia, Propofol Pharmacodynamics, Propofol Target Controlled Infusion","enrollment":14}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["propofol TCI"],"phase":"marketed","status":"active","brandName":"propofol targel controlled infusion","genericName":"propofol targel controlled infusion","companyName":"Universidad del Desarrollo","companyId":"universidad-del-desarrollo","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Propofol is a short-acting intravenous anesthetic that enhances inhibitory GABA neurotransmission in the central nervous system to produce sedation and anesthesia. Used for Induction and maintenance of general anesthesia, Sedation in intensive care units, Sedation for diagnostic and therapeutic procedures.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}