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Propofol/Lidocaine
Propofol and lidocaine together provide rapid induction and maintenance of anesthesia with reduced pain on injection through synergistic central nervous system depression.
Propofol and lidocaine together provide rapid induction and maintenance of anesthesia with reduced pain on injection through synergistic central nervous system depression. Used for Induction and maintenance of general anesthesia, Sedation in intensive care units.
At a glance
| Generic name | Propofol/Lidocaine |
|---|---|
| Also known as | Propofol, Fospropofol, Pain on Injection |
| Sponsor | NYU Langone Health |
| Drug class | Intravenous anesthetic combination |
| Target | GABA-A receptor (propofol); voltage-gated sodium channels (lidocaine) |
| Modality | Small molecule |
| Therapeutic area | Anesthesiology |
| Phase | FDA-approved |
Mechanism of action
Propofol is an intravenous anesthetic that enhances GABA-mediated inhibition in the central nervous system, producing sedation and unconsciousness. Lidocaine, a local anesthetic, blocks sodium channels and is added to the formulation to reduce the pain and burning sensation that occurs during propofol injection. The combination leverages propofol's anesthetic efficacy while mitigating a common adverse effect.
Approved indications
- Induction and maintenance of general anesthesia
- Sedation in intensive care units
Common side effects
- Injection site pain (reduced vs. propofol alone)
- Hypotension
- Respiratory depression
- Bradycardia
- Apnea
Key clinical trials
- The Relationship Between Opioid-Free Anesthesia and Postoperative Agitation-Delirium and Quality of Recovery in Pediatric Ear, Nose, and Throat Cases Monitored With Perioperative Bispectral Index
- Effects of Different Drugs for Glottic Atomization on Postoperative Sore Throat After Thyroid Surgery (PHASE4)
- Study Comparing Local/ MAC Anesthesia in Lumbar Decompression (EARLY_PHASE1)
- General Anesthesia and General Anesthesia Combined With Thoracic Epidural Anesthesia (NA)
- Effect of IV Lidocaine on Duodenal Peristalsis and Sedation in ERCP (PHASE4)
- Lidocaine-based Versus Opioid-based Induction of Anesthesia in Emergency Laparotomy (PHASE4)
- Comparison of Airway Management With Bronchial Blocker and Double-Lumen Tube in Single-Lung Ventilation (NA)
- Tubeless Strategy in Lung Transplantation: A Prospective Single-Arm Study (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Propofol/Lidocaine CI brief — competitive landscape report
- Propofol/Lidocaine updates RSS · CI watch RSS
- NYU Langone Health portfolio CI