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Prone hyperpolarized 3 helium gas scan
Hyperpolarized helium-3 gas imaging is a diagnostic imaging technique that uses polarized helium-3 gas inhaled by patients to visualize lung ventilation and detect regional ventilation defects.
Hyperpolarized helium-3 gas imaging is a diagnostic imaging technique that uses polarized helium-3 gas inhaled by patients to visualize lung ventilation and detect regional ventilation defects. Used for Pulmonary ventilation imaging in obstructive airway disease, Detection and assessment of emphysema, Evaluation of regional lung function in cystic fibrosis and asthma.
At a glance
| Generic name | Prone hyperpolarized 3 helium gas scan |
|---|---|
| Also known as | Prone MRI scan with contrast |
| Sponsor | Eric A. Hoffman |
| Modality | Small molecule |
| Therapeutic area | Pulmonology / Respiratory |
| Phase | FDA-approved |
Mechanism of action
Helium-3 atoms are hyperpolarized to a high spin state, making them detectable by magnetic resonance imaging (MRI). When inhaled, the gas distributes throughout the lungs according to ventilation patterns. MRI detection of the polarized helium-3 signal reveals ventilation distribution, allowing visualization of areas with poor or absent ventilation that may indicate obstructive airway disease, emphysema, or other pulmonary pathology.
Approved indications
- Pulmonary ventilation imaging in obstructive airway disease
- Detection and assessment of emphysema
- Evaluation of regional lung function in cystic fibrosis and asthma
Common side effects
Key clinical trials
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Prone hyperpolarized 3 helium gas scan CI brief — competitive landscape report
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- Eric A. Hoffman portfolio CI