{"id":"prone-hyperpolarized-3-helium-gas-scan","safety":{"commonSideEffects":[]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Helium-3 atoms are hyperpolarized to a high spin state, making them detectable by magnetic resonance imaging (MRI). When inhaled, the gas distributes throughout the lungs according to ventilation patterns. MRI detection of the polarized helium-3 signal reveals ventilation distribution, allowing visualization of areas with poor or absent ventilation that may indicate obstructive airway disease, emphysema, or other pulmonary pathology.","oneSentence":"Hyperpolarized helium-3 gas imaging is a diagnostic imaging technique that uses polarized helium-3 gas inhaled by patients to visualize lung ventilation and detect regional ventilation defects.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:36:40.681Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Pulmonary ventilation imaging in obstructive airway disease"},{"name":"Detection and assessment of emphysema"},{"name":"Evaluation of regional lung function in cystic fibrosis and asthma"}]},"trialDetails":[{"nctId":"NCT03776747","phase":"PHASE4","title":"Repeatability in Hyperpolarized 3-Helium With MRI","status":"COMPLETED","sponsor":"Eric A. Hoffman","startDate":"2008-07-22","conditions":"Radiation Exposure","enrollment":18}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Prone MRI scan with contrast"],"phase":"marketed","status":"active","brandName":"Prone hyperpolarized 3 helium gas scan","genericName":"Prone hyperpolarized 3 helium gas scan","companyName":"Eric A. Hoffman","companyId":"eric-a-hoffman","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Hyperpolarized helium-3 gas imaging is a diagnostic imaging technique that uses polarized helium-3 gas inhaled by patients to visualize lung ventilation and detect regional ventilation defects. Used for Pulmonary ventilation imaging in obstructive airway disease, Detection and assessment of emphysema, Evaluation of regional lung function in cystic fibrosis and asthma.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":false,"trials":true,"score":3}}