Repeatability in Hyperpolarized 3-Helium Magnetic Resonance Imaging

NCT03776747 Phase 4 COMPLETED Results posted

The main purpose of this study is to assess and test the reproducibility and results of hyperpolarized 3-Helium gas as a contrast agent with Magnetic Resonance Imaging (MRI) of the lungs in healthy adult subjects.

Details

Lead sponsor	Eric A. Hoffman
Phase	Phase 4
Status	COMPLETED
Enrolment	18
Start date	2008-07-22
Completion	2012-06

Conditions

• Radiation Exposure

Interventions

• Prone hyperpolarized 3 helium gas scan
• Supine hyperpolarized 3 helium gas scan
• Vitals
• Pulmonary Function Tests
• Initial protocol MRI scan

Primary outcomes

• Apparent Diffusion Coefficient (ADC) as a Function of Lung Inflation Levels. — Through study completion, measurements completed at one day visit only.
  Validate the intrinsic variability of ADC (cm2/s) as a function of normal procedural and physiological changes in an attempt to standardize the use of the biomarker in future assessments of pulmonary pathologies.

Countries

United States