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Progesterone in Oil (PIO) Only
Progesterone in Oil (PIO) Only is a Progestin; Hormone replacement Small molecule drug developed by Shady Grove Fertility Reproductive Science Center. It is currently FDA-approved for Luteal phase support in assisted reproductive technology (ART) cycles, Early pregnancy maintenance in infertility treatment. Also known as: Progesterone in Sesame Oil Injection.
Progesterone in oil provides exogenous progesterone to support the luteal phase and maintain early pregnancy by supplementing endogenous progesterone production.
Progesterone in oil provides exogenous progesterone to support the luteal phase and maintain early pregnancy by supplementing endogenous progesterone production. Used for Luteal phase support in assisted reproductive technology (ART) cycles, Early pregnancy maintenance in infertility treatment.
At a glance
| Generic name | Progesterone in Oil (PIO) Only |
|---|---|
| Also known as | Progesterone in Sesame Oil Injection |
| Sponsor | Shady Grove Fertility Reproductive Science Center |
| Drug class | Progestin; Hormone replacement |
| Target | Progesterone receptor (PR) |
| Modality | Small molecule |
| Therapeutic area | Reproductive/Fertility |
| Phase | FDA-approved |
Mechanism of action
Progesterone is a naturally occurring steroid hormone essential for preparing and maintaining the uterine endometrium for embryo implantation and pregnancy. In assisted reproductive technology, exogenous progesterone supplementation compensates for inadequate corpus luteum function, ensuring sufficient endometrial receptivity and preventing premature menstruation. The oil formulation provides sustained intramuscular absorption and prolonged systemic progesterone levels.
Approved indications
- Luteal phase support in assisted reproductive technology (ART) cycles
- Early pregnancy maintenance in infertility treatment
Common side effects
- Injection site pain or irritation
- Breast tenderness
- Bloating or abdominal discomfort
- Mood changes
- Headache
Key clinical trials
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Progesterone in Oil (PIO) Only CI brief — competitive landscape report
- Progesterone in Oil (PIO) Only updates RSS · CI watch RSS
- Shady Grove Fertility Reproductive Science Center portfolio CI
Frequently asked questions about Progesterone in Oil (PIO) Only
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Related
- Drug class: All Progestin; Hormone replacement drugs
- Target: All drugs targeting Progesterone receptor (PR)
- Manufacturer: Shady Grove Fertility Reproductive Science Center — full pipeline
- Therapeutic area: All drugs in Reproductive/Fertility
- Indication: Drugs for Luteal phase support in assisted reproductive technology (ART) cycles
- Indication: Drugs for Early pregnancy maintenance in infertility treatment
- Also known as: Progesterone in Sesame Oil Injection
- Compare: Progesterone in Oil (PIO) Only vs similar drugs
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