Who are Progesterone in Oil (PIO) Only's main competitors?

Direct comparators (same drug class / molecular target / therapeutic area): Slynd, Natazia, Mifeprex, Ortho-Cept, Delalutin, Megace.

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Every 30 minutes from primary sources (FDA, EMA, MHRA, PMDA, ClinicalTrials.gov, USPTO). Subscribe to the RSS feed below for push alerts.

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Last reviewed 2026-05-17 · How we verify

Progesterone in Oil (PIO) Only — Competitive Intelligence Brief

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Progesterone in Oil (PIO) Only (Progesterone in Oil (PIO) Only) competitive landscape: 6 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: Progestin; Hormone replacement. Area: Reproductive/Fertility.

marketed Progestin; Hormone replacement Progesterone receptor (PR) Reproductive/Fertility Small molecule Live · refreshed every 30 min

Target snapshot

Progesterone in Oil (PIO) Only (Progesterone in Oil (PIO) Only) — Shady Grove Fertility Reproductive Science Center. Progesterone in oil provides exogenous progesterone to support the luteal phase and maintain early pregnancy by supplementing endogenous progesterone production.

Comparator set (6 drugs)

Auto-detected by same drug class / molecular target / therapeutic area, ranked by phase + recency. Override with ?vs=slug1,slug2,….

Drug	Generic	Sponsor	Phase	Class	Target	Approval / PDUFA
Progesterone in Oil (PIO) Only TARGET	Progesterone in Oil (PIO) Only	Shady Grove Fertility Reproductive Science Center	marketed	Progestin; Hormone replacement	Progesterone receptor (PR)
Slynd	DROSPIRENONE	Exeltis Usa Inc	marketed	Progestin	Mineralocorticoid receptor	2019-01-01
Natazia	DIENOGEST	Mochida Pharmaceutical Co., Ltd.	marketed	Progestin	Progesterone receptor	2010-01-01
Mifeprex	MIFEPRISTONE	Corcept Therap	marketed	Progestin Antagonist [EPC]	Glucocorticoid receptor	2000-01-01
Ortho-Cept	DESOGESTREL	Merck & Co.	marketed	Progestin	Sex hormone-binding globulin	1992-01-01
Delalutin	HYDROXYPROGESTERONE CAPROATE	Bristol-Myers Squibb	marketed	Progestin	Corticosteroid-binding globulin	1975-01-01
Megace	MEGESTROL ACETATE	Bristol-Myers Squibb	marketed	Progestin	Glucocorticoid receptor	1971-01-01

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

2028-01-30 — Natazia · 8153616 · US

Sponsor landscape (Progestin; Hormone replacement class)

Shady Grove Fertility Reproductive Science Center · 1 drug in this class

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Cite this brief

Drug Landscape (2026). Progesterone in Oil (PIO) Only — Competitive Intelligence Brief. https://druglandscape.com/ci/progesterone-in-oil-pio-only. Accessed 2026-05-17.

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