{"id":"progesterone-in-oil-pio-only","safety":{"commonSideEffects":[{"rate":null,"effect":"Injection site pain or irritation"},{"rate":null,"effect":"Breast tenderness"},{"rate":null,"effect":"Bloating or abdominal discomfort"},{"rate":null,"effect":"Mood changes"},{"rate":null,"effect":"Headache"}]},"_chembl":{"chemblId":"CHEMBL2107910","moleculeType":"Unknown"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Progesterone is a naturally occurring steroid hormone essential for preparing and maintaining the uterine endometrium for embryo implantation and pregnancy. In assisted reproductive technology, exogenous progesterone supplementation compensates for inadequate corpus luteum function, ensuring sufficient endometrial receptivity and preventing premature menstruation. The oil formulation provides sustained intramuscular absorption and prolonged systemic progesterone levels.","oneSentence":"Progesterone in oil provides exogenous progesterone to support the luteal phase and maintain early pregnancy by supplementing endogenous progesterone production.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:02:49.195Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Luteal phase support in assisted reproductive technology (ART) cycles"},{"name":"Early pregnancy maintenance in infertility treatment"}]},"trialDetails":[{"nctId":"NCT02254577","phase":"PHASE4","title":"Vaginal Compared to Intramuscular Progesterone for Frozen Embryo Transfer","status":"COMPLETED","sponsor":"Shady Grove Fertility Reproductive Science Center","startDate":"2014-10","conditions":"Infertility","enrollment":1139}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Progesterone in Sesame Oil Injection"],"phase":"marketed","status":"active","brandName":"Progesterone in Oil (PIO) Only","genericName":"Progesterone in Oil (PIO) Only","companyName":"Shady Grove Fertility Reproductive Science Center","companyId":"shady-grove-fertility-reproductive-science-center","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Progesterone in oil provides exogenous progesterone to support the luteal phase and maintain early pregnancy by supplementing endogenous progesterone production. Used for Luteal phase support in assisted reproductive technology (ART) cycles, Early pregnancy maintenance in infertility treatment.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}