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Preservative-Free Timolol maleate
Preservative-Free Timolol maleate is a Non-selective beta-adrenergic antagonist Small molecule drug developed by Merck Sharp & Dohme LLC. It is currently in Phase 3 development for Open-angle glaucoma, Ocular hypertension. Also known as: Preservative-Free Timoptic.
Timolol maleate is a non-selective beta-adrenergic receptor antagonist that reduces intraocular pressure by decreasing aqueous humor production in the eye.
Timolol maleate is a non-selective beta-adrenergic receptor antagonist that reduces intraocular pressure by decreasing aqueous humor production in the eye. Used for Open-angle glaucoma, Ocular hypertension.
At a glance
| Generic name | Preservative-Free Timolol maleate |
|---|---|
| Also known as | Preservative-Free Timoptic |
| Sponsor | Merck Sharp & Dohme LLC |
| Drug class | Non-selective beta-adrenergic antagonist |
| Target | Beta-1 and beta-2 adrenergic receptors |
| Modality | Small molecule |
| Therapeutic area | Ophthalmology |
| Phase | Phase 3 |
Mechanism of action
Timolol blocks beta-1 and beta-2 adrenergic receptors in the ciliary body of the eye, which reduces the rate of aqueous humor formation. This leads to a decrease in intraocular pressure, making it effective for treating glaucoma and ocular hypertension. The preservative-free formulation minimizes ocular surface irritation and is suitable for patients with sensitive eyes or those using multiple topical medications.
Approved indications
- Open-angle glaucoma
- Ocular hypertension
Common side effects
- Ocular irritation or discomfort
- Blurred vision
- Conjunctival hyperemia
- Systemic beta-blocker effects (bradycardia, bronchospasm in susceptible patients)
Key clinical trials
- Study of an Investigational Product, QLS-111, Provided as an Eyedrop, for Treatment of Normal Tension Glaucoma (NTG) (PHASE2)
- PRO-122 Versus Concomitant Therapy in Subjects With Uncontrolled Primary Open-angle Glaucoma (PRO-122LATAM) (PHASE3)
- A Study to Evaluate Safety and Tolerability of QLS-101 in NTG (PHASE2)
- Study to Evaluate QLS-101 Compared to Timolol Maleate Eye Drops in Subjects With High Eye Pressure (Glaucoma or Ocular Hypertension). (PHASE2)
- Dorzolamide+Timolol Multidose Preservative-free vs Dorzolamida+Timolol BAK Preserved Efficacy and Safety (PHASE4)
- Impact of Timolol/Dorzolamide Therapy on Autoregulation in Glaucoma Patients (PHASE4)
- Comparative Study of the Efficacy of Either Krytantek Ofteno PF® or Eliptic Ofteno PF® Plus Gaap Ofteno PF® for POAG or Ocular Hypertension. (PHASE4)
- A Study of DE-111A on the Treatment of Open Angle Glaucoma or Ocular Hypertension (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Preservative-Free Timolol maleate CI brief — competitive landscape report
- Preservative-Free Timolol maleate updates RSS · CI watch RSS
- Merck Sharp & Dohme LLC portfolio CI
Frequently asked questions about Preservative-Free Timolol maleate
What is Preservative-Free Timolol maleate?
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What is Preservative-Free Timolol maleate used for?
Who makes Preservative-Free Timolol maleate?
Is Preservative-Free Timolol maleate also known as anything else?
What drug class is Preservative-Free Timolol maleate in?
What development phase is Preservative-Free Timolol maleate in?
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What does Preservative-Free Timolol maleate target?
Related
- Drug class: All Non-selective beta-adrenergic antagonist drugs
- Target: All drugs targeting Beta-1 and beta-2 adrenergic receptors
- Manufacturer: Merck Sharp & Dohme LLC — full pipeline
- Therapeutic area: All drugs in Ophthalmology
- Indication: Drugs for Open-angle glaucoma
- Indication: Drugs for Ocular hypertension
- Also known as: Preservative-Free Timoptic
- Compare: Preservative-Free Timolol maleate vs similar drugs
- Pricing: Preservative-Free Timolol maleate cost, discount & access