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preoperative normal saline inhalation
Normal saline inhalation administered preoperatively hydrates and clears the respiratory tract to optimize airway conditions before surgery.
Normal saline inhalation administered preoperatively hydrates and clears the respiratory tract to optimize airway conditions before surgery. Used for Preoperative airway preparation and hydration, Reduction of postoperative respiratory complications.
At a glance
| Generic name | preoperative normal saline inhalation |
|---|---|
| Sponsor | Fujian Medical University Union Hospital |
| Drug class | Inhalation solution / Mucosal hydrating agent |
| Modality | Small molecule |
| Therapeutic area | Perioperative Medicine / Respiratory |
| Phase | FDA-approved |
Mechanism of action
Inhaled normal saline (0.9% sodium chloride solution) acts as a mucosal hydrating agent that moistens the airways and helps mobilize and clear secretions from the respiratory tract. This preoperative preparation reduces airway irritation, improves mucociliary clearance, and may decrease postoperative respiratory complications by ensuring optimal airway patency at the time of anesthesia induction.
Approved indications
- Preoperative airway preparation and hydration
- Reduction of postoperative respiratory complications
Common side effects
- Mild throat irritation
- Cough
- Transient bronchospasm (rare)
Key clinical trials
- Prophylactic Penehyclidine Hydrochloride Inhalation and 3-year Outcome After Surgery (PHASE4)
- Atomized Inhalation ICG for Treatment of Congenital Lung Malformations (NA)
- Comparison of Preoperative Inhaled Budesonide With Salbutamol on the Respiratory Adverse Effects in Children Undergoing Tonsillectomy (PHASE4)
- The Effect of Upper Transabdominal Plain Block on Diaphragm Thickness
- Ketamine or Neostigmine for Serratus Anterior Plane Block in Modified Radical Mastectomy (NA)
- Preventive Effects of Penehyclidine Hydrochloride Inhalation on Postoperative Pulmonary Complications (PHASE4)
- Effect of Preoperative Budesonide Inhalation on Arterial Blood Oxygenation and Intrapulmonary Shunt During OLV (PHASE4)
- Preoperative Dexmedetomidine & EC50 of Propofol (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
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