Preoperative Dexmedetomidine Reduces the EC50 of Propofol for Successful i-gelTM Insertion Without Muscle Relaxants (PreopDXM)

NCT02097407 Phase 4 COMPLETED

Dexmedetomidine is a useful anaesthetic adjuvant for general anaesthesia. In this prospective randomised study, we determined whether preoperative dexmedetomidine administration could reduce the half maximal effective concentration (EC50) of propofol for successful i-gelTM insertion without muscle relaxants.

Details

Lead sponsor	Seoul National University Hospital
Phase	Phase 4
Status	COMPLETED
Enrolment	37
Start date	2012-05
Completion	2012-08

Conditions

• Urologic Surgery

Interventions

• Group C : Saline + propofol group
• Group D : Dexmedetomidine + propofol group

Primary outcomes

• EC50 of propofol required for successful i-gel insertion — During i-gel insertion anticipated up to 1 min
  The EC50 of propofol for successful i-gel insertion was determined by a modification of Dixon's up-and-down method. The response of each patient determined the effect-site propofol concentration for the next patient. If the response was deemed 'successful', the next target concentration of propofol was decreased by 0.5 µg mL-1. If the response was deemed a 'failure', the target concentration was increased by the same dose. The process was repeated until the sixth crossover point (success/failure) was obtained.

Countries

South Korea