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Povidone-Iodine Scrub and Paint
Povidone-iodine acts as a broad-spectrum antimicrobial agent that releases iodine to disrupt microbial cell membranes and proteins, providing rapid antiseptic and disinfectant activity.
Povidone-iodine acts as a broad-spectrum antimicrobial agent that releases iodine to disrupt microbial cell membranes and proteins, providing rapid antiseptic and disinfectant activity. Used for Skin antisepsis prior to surgery or medical procedures, Wound disinfection and cleansing, Prevention of infection in minor cuts and abrasions.
At a glance
| Generic name | Povidone-Iodine Scrub and Paint |
|---|---|
| Also known as | Betadine |
| Sponsor | Case Western Reserve University |
| Drug class | Antiseptic/Disinfectant |
| Modality | Small molecule |
| Therapeutic area | Infection Prevention / Dermatology |
| Phase | FDA-approved |
Mechanism of action
Povidone-iodine is a complex of iodine with polyvinylpyrrolidone (povidone) that slowly releases iodine in solution. The iodine penetrates microbial cell walls and oxidizes essential proteins and nucleic acids, leading to cell death. It is effective against bacteria, viruses, fungi, and some protozoa, making it suitable for skin antisepsis and wound disinfection.
Approved indications
- Skin antisepsis prior to surgery or medical procedures
- Wound disinfection and cleansing
- Prevention of infection in minor cuts and abrasions
Common side effects
- Skin irritation or erythema
- Allergic contact dermatitis
- Iodine sensitivity reactions
Key clinical trials
- Pilot Evaluation of the Application Procedure on the Antimicrobial Effects of 2 Antiseptics (PHASE3)
- Chlorhexidine-Alcohol Versus Povidone-Iodine for Cesarean Antisepsis (NA)
- Chlorhexidine Gluconate Versus Povidone-Iodine as Vaginal Preparation Antiseptics Prior to Cesarean Delivery (PHASE4)
- Prospective Randomized Controlled Multicenter Trial of 4 Antiseptic Strategies for Prevention of Catheter Infection in Intensive Care Unit for Adults Patients (PHASE4)
- Efficacy Study of Antiseptic Preoperative Scrubs in Prevention of Postoperative Infections (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Povidone-Iodine Scrub and Paint CI brief — competitive landscape report
- Povidone-Iodine Scrub and Paint updates RSS · CI watch RSS
- Case Western Reserve University portfolio CI