{"id":"povidone-iodine-scrub-and-paint","safety":{"commonSideEffects":[{"rate":null,"effect":"Skin irritation or erythema"},{"rate":null,"effect":"Allergic contact dermatitis"},{"rate":null,"effect":"Iodine sensitivity reactions"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Povidone-iodine is a complex of iodine with polyvinylpyrrolidone (povidone) that slowly releases iodine in solution. The iodine penetrates microbial cell walls and oxidizes essential proteins and nucleic acids, leading to cell death. It is effective against bacteria, viruses, fungi, and some protozoa, making it suitable for skin antisepsis and wound disinfection.","oneSentence":"Povidone-iodine acts as a broad-spectrum antimicrobial agent that releases iodine to disrupt microbial cell membranes and proteins, providing rapid antiseptic and disinfectant activity.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:42:16.703Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Skin antisepsis prior to surgery or medical procedures"},{"name":"Wound disinfection and cleansing"},{"name":"Prevention of infection in minor cuts and abrasions"}]},"trialDetails":[{"nctId":"NCT00692484","phase":"PHASE3","title":"Pilot Evaluation of the Application Procedure on the Antimicrobial Effects of 2 Antiseptics","status":"COMPLETED","sponsor":"C. R. Bard","startDate":"2007-10","conditions":"Healthy","enrollment":122},{"nctId":"NCT02202577","phase":"NA","title":"Chlorhexidine-Alcohol Versus Povidone-Iodine for Cesarean Antisepsis","status":"COMPLETED","sponsor":"Case Western Reserve University","startDate":"2014-03","conditions":"Surgical Site Infection","enrollment":932},{"nctId":"NCT03133312","phase":"PHASE4","title":"Chlorhexidine Gluconate Versus Povidone-Iodine as Vaginal Preparation Antiseptics Prior to Cesarean Delivery","status":"COMPLETED","sponsor":"Metro Health, Michigan","startDate":"2017-05-02","conditions":"Infection, Bacterial","enrollment":100},{"nctId":"NCT01629550","phase":"PHASE4","title":"Prospective Randomized Controlled Multicenter Trial of 4 Antiseptic Strategies for Prevention of Catheter Infection in Intensive Care Unit for Adults Patients","status":"COMPLETED","sponsor":"Poitiers University Hospital","startDate":"2012-10","conditions":"Preventing Catheter Related Infection","enrollment":2400},{"nctId":"NCT00290290","phase":"PHASE3","title":"Efficacy Study of Antiseptic Preoperative Scrubs in Prevention of Postoperative Infections","status":"COMPLETED","sponsor":"Baylor College of Medicine","startDate":"2003-09","conditions":"Postoperative Wound Infection","enrollment":849}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":16,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Betadine"],"phase":"marketed","status":"active","brandName":"Povidone-Iodine Scrub and Paint","genericName":"Povidone-Iodine Scrub and Paint","companyName":"Case Western Reserve University","companyId":"case-western-reserve-university","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Povidone-iodine acts as a broad-spectrum antimicrobial agent that releases iodine to disrupt microbial cell membranes and proteins, providing rapid antiseptic and disinfectant activity. Used for Skin antisepsis prior to surgery or medical procedures, Wound disinfection and cleansing, Prevention of infection in minor cuts and abrasions.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}