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Peri-Portal Block Group
A regional anesthesia technique that blocks nerve conduction in the peri-portal venous plexus to provide anesthesia for hepatic surgical procedures.
A regional anesthesia technique that blocks nerve conduction in the peri-portal venous plexus to provide anesthesia for hepatic surgical procedures. Used for Anesthesia for hepatic and hepatobiliary surgical procedures, Pain management during liver resection and transplantation.
At a glance
| Generic name | Peri-Portal Block Group |
|---|---|
| Also known as | 0.5% Bupivacaine |
| Sponsor | Mayo General Hospital, Ireland |
| Modality | Small molecule |
| Therapeutic area | Anesthesia/Surgery |
| Phase | Phase 3 |
Mechanism of action
The peri-portal block targets the nerve fibers surrounding the portal vein and hepatic vasculature, interrupting sensory and motor innervation to the liver and surrounding structures. This regional anesthesia approach is used during hepatobiliary surgery to reduce pain and potentially decrease systemic anesthetic requirements. The technique involves injection of local anesthetic agents around the portal vein complex under imaging guidance.
Approved indications
- Anesthesia for hepatic and hepatobiliary surgical procedures
- Pain management during liver resection and transplantation
Common side effects
- Local anesthetic toxicity
- Vascular puncture/bleeding
- Organ perforation
- Infection at injection site
Key clinical trials
- Knee Arthroscopy for Pain Control (NA)
- Adrenergic System in Islet Transplantation (EARLY_PHASE1)
- Intra-articular Analgesia Versus Adductor Canal Block for Arthroscopic Knee Surgery (PHASE3)
- PVB Versus TAP in Hepatic Patients Undergoing Laparoscopic Cholecystectomy (NA)
- Sleeve Gastrectomy: Outcome, Morbidity and Mortality. A Multicentric Retrospective Trial
- Lap TAP Block for Laparoscopic TEP Inguinal Hernia Repair: a Prospective, Double-blinded, Randomized, Clinical Trial (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Peri-Portal Block Group CI brief — competitive landscape report
- Peri-Portal Block Group updates RSS · CI watch RSS
- Mayo General Hospital, Ireland portfolio CI