{"id":"peri-portal-block-group","safety":{"commonSideEffects":[{"rate":null,"effect":"Local anesthetic toxicity"},{"rate":null,"effect":"Vascular puncture/bleeding"},{"rate":null,"effect":"Organ perforation"},{"rate":null,"effect":"Infection at injection site"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"The peri-portal block targets the nerve fibers surrounding the portal vein and hepatic vasculature, interrupting sensory and motor innervation to the liver and surrounding structures. This regional anesthesia approach is used during hepatobiliary surgery to reduce pain and potentially decrease systemic anesthetic requirements. The technique involves injection of local anesthetic agents around the portal vein complex under imaging guidance.","oneSentence":"A regional anesthesia technique that blocks nerve conduction in the peri-portal venous plexus to provide anesthesia for hepatic surgical procedures.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T00:49:17.025Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Anesthesia for hepatic and hepatobiliary surgical procedures"},{"name":"Pain management during liver resection and transplantation"}]},"trialDetails":[{"nctId":"NCT06701175","phase":"NA","title":"Knee Arthroscopy for Pain Control","status":"WITHDRAWN","sponsor":"University of Alabama at Birmingham","startDate":"2025-12","conditions":"Knee Arthroscopy","enrollment":""},{"nctId":"NCT03079921","phase":"EARLY_PHASE1","title":"Adrenergic System in Islet Transplantation","status":"ACTIVE_NOT_RECRUITING","sponsor":"University of Pennsylvania","startDate":"2017-01-20","conditions":"Type1diabetes, Hypoglycemia, Hypoglycemia Unawareness","enrollment":11},{"nctId":"NCT05004506","phase":"PHASE3","title":"Intra-articular Analgesia Versus Adductor Canal Block for Arthroscopic Knee Surgery","status":"UNKNOWN","sponsor":"Loyola University","startDate":"2016-04-20","conditions":"Post-Operative Pain, Chronic","enrollment":100},{"nctId":"NCT04208165","phase":"NA","title":"PVB Versus TAP in Hepatic Patients Undergoing Laparoscopic Cholecystectomy","status":"COMPLETED","sponsor":"Theodor Bilharz Research Institute","startDate":"2019-12-29","conditions":"Ultrasound Therapy, Hepatic Impairment, Laparoscopic Cholecystectomy","enrollment":60},{"nctId":"NCT04643262","phase":"","title":"Sleeve Gastrectomy: Outcome, Morbidity and Mortality. A Multicentric Retrospective Trial","status":"ENROLLING_BY_INVITATION","sponsor":"Azienda Sanitaria Locale Napoli 2 Nord","startDate":"2015-01-01","conditions":"Morbid Obesity","enrollment":10000},{"nctId":"NCT02632136","phase":"PHASE3","title":"Lap TAP Block for Laparoscopic TEP Inguinal Hernia Repair: a Prospective, Double-blinded, Randomized, Clinical Trial","status":"UNKNOWN","sponsor":"Mayo General Hospital, Ireland","startDate":"2015-11","conditions":"Laparoscopic TAP Block in TEP Inguinal Hernia Repair.","enrollment":86}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["0.5% Bupivacaine"],"phase":"phase_3","status":"active","brandName":"Peri-Portal Block Group","genericName":"Peri-Portal Block Group","companyName":"Mayo General Hospital, Ireland","companyId":"mayo-general-hospital-ireland","modality":"Small molecule","firstApprovalDate":"","aiSummary":"A regional anesthesia technique that blocks nerve conduction in the peri-portal venous plexus to provide anesthesia for hepatic surgical procedures. Used for Anesthesia for hepatic and hepatobiliary surgical procedures, Pain management during liver resection and transplantation.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}